{"doi":"10.1111/ajt.15366","title":"The neonatal Fc receptor: Key to homeostasic control of IgG and IgG-related biopharmaceuticals","abstract":null,"journal":"American Journal of Transplantation","year":2019,"id":623761,"datarank":1.4966680646042305,"base_score":4.060443010546419,"endowment":4.060443010546419,"self_citation_contribution":0.6090664515819629,"citation_network_contribution":0.8876016130222676,"self_endowment_contribution":0.6090664515819629,"citer_contribution":0.8876016130222676,"corpus_percentile":null,"corpus_rank":null,"citation_count":57,"citer_count":55,"citers_with_citation_signal":36,"citers_with_endowment":36,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":505238,"name":"Anna Valujskikh","orcid":"0000-0003-3252-0636","position":1,"is_corresponding":false},{"id":72293,"name":"Robert L. Fairchild","orcid":"0000-0002-7107-5259","position":2,"is_corresponding":false},{"id":278887,"name":"William M. Baldwin","orcid":"0000-0002-7271-1827","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The neonatal Fc receptor: Key to homeostasic control of IgG and IgG-related biopharmaceuticals","abstract":"IgG and albumin are the most abundant proteins in the circulation and have the longest half-lives. These properties are due to a unique receptor, the neonatal Fc receptor (FcRn). Although FcRn is named for its function of transferring IgG across the placenta from maternal to fetal circulation, FcRn functions throughout life to maintain IgG and albumin concentrations. FcRn protects IgG and albumin from intracellular degradation and recycles them back into the circulation. Clinical trials have confirmed that pathogenic antibodies can be depleted by blocking this homeostatic function of FcRn. Moreover, understanding the molecular interactions between IgG and FcRn has resulted in the design of therapeutic monoclonal antibodies with more efficacious pharmacokinetics. As a result of genetic engineering these monoclonals can be delivered at lower doses and at longer intervals. More recent findings have demonstrated that FcRn enhances phagocytosis by neutrophils, immune complex clearance by podocytes and antigen presentation by dendritic cells, macrophages, and B cells. This minireview highlights the relevance of FcRn to transplantation.","is_dataset_classified":null,"base_score":4.060443010546419,"endowment":4.060443010546419,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30903736","pmcid":"PMC6591018","openalex_id":"https://openalex.org/W2937854937","authors":[],"funders":[{"funder_name":"National Institute of Allergy and Infectious Diseases","grant_id":"NIH PO1 AI087506","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"P01 AI087586","title":null}],"total_grants":2,"fwci":1.3754,"citation_percentile":0.80465886,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2022,"count":1},{"year":2023,"count":11},{"year":2024,"count":13},{"year":2025,"count":11},{"year":2026,"count":13}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ajt.15366","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ajt.15366","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/ajt.15366","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ajt.15366","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1600613522091420?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1600613522091420?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1111/ajt.15366","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30903736","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6591018","host_type":"repository"}],"fields_of_study":["Monoclonal and Polyclonal Antibodies Research","Complement system in diseases","Blood groups and transfusion","Antigen Presentation","Biological Products","Histocompatibility Antigens Class I","Homeostasis","Humans","Immunoglobulin G","Phagocytosis","Receptors, Fc"],"mesh_terms":["Biological Products","Homeostasis","Humans","Immunoglobulin G","Phagocytosis","Receptors, Fc","Histocompatibility Antigens Class I","Antigen Presentation"],"keywords":["Neonatal Fc receptor","Antibody","Immunoglobulin G","Albumin","Receptor","Fetal circulation","Immunology","Fragment crystallizable region","Immune system","Serum albumin","Medicine","Placenta","Biology","Fetus","Cell biology","Internal medicine","Pregnancy","Immune regulation","immunobiology","bioengineering","Sensitization","Alloantibody","Cellular Biology","Translational Research/science","Immunosuppression/immune Modulation","Immunosuppressant - Fusion Proteins And Monoclonal Antibodies"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T01:16:04.895105Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}