{"doi":"10.1111/ajd.14152","title":"Association between acetaminophen use and vitiligo in <scp>US</scp> women and men","abstract":"BACKGROUND/OBJECTIVES: Exposure to chemical phenols, which can act as tyrosine analogues and result in anti-melanocyte autoimmunity, has been associated with vitiligo. Acetaminophen (N-acetyl-p-aminophenol) is an over-the-counter analgesic of phenolic origin. The risk of vitiligo with systemic exposure to acetaminophen has not yet been evaluated. METHODS: We examined the risk of vitiligo with regular use acetaminophen in women, the Nurses' Health Study (NHS) and in men, the Health Professionals Follow-up Study (HPFS). Regular acetaminophen use was asked biennially from 1990 in NHS and from 1986 in HPFS, and the year of clinician-diagnosed vitiligo was asked retrospectively in 2012 in the cohorts. RESULTS: In NHS, a total of 161 vitiligo cases were identified during a follow-up of 571,724 person-years; in HPFS, a total of 183 vitiligo cases were identified during a follow-up of 680,313 person-years. Regular use of acetaminophen was associated with an increased vitiligo risk in NHS but not HPFS. The multivariable relative risk (RR) was 1.52 (95% confidence interval [CI] 1.03-2.25) in NHS and 1.09 (95% CI 0.76-1.55) in HPFS. The higher risk of vitiligo was similar by duration of acetaminophen use in women; the multivariable RRs were 1.47 (95% CI 0.98-2.21) for acetaminophen use under 5 years, and 1.78 (95% CI 1.11-2.84) for acetaminophen use over 5 years. CONCLUSIONS: Acetaminophen may be associated with a higher risk of vitiligo in women.","journal":"Australasian Journal of Dermatology","year":2023,"id":383684,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9657,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":320858,"name":"Brian M. Lin","orcid":"0000-0002-8991-8082","position":1,"is_corresponding":false},{"id":545471,"name":"Vivian Wong","orcid":"0000-0003-0135-9990","position":2,"is_corresponding":false},{"id":257719,"name":"Wenqing Li","orcid":"0000-0002-8336-5552","position":3,"is_corresponding":false},{"id":1150746,"name":"Victor Huang","orcid":"0000-0001-7014-8084","position":4,"is_corresponding":false},{"id":325327,"name":"John E. Harris","orcid":"0000-0002-7815-6430","position":5,"is_corresponding":false},{"id":1150747,"name":"Khaled Ezzedine","orcid":"0000-0002-5468-4589","position":6,"is_corresponding":false},{"id":284194,"name":"Eunyoung Cho","orcid":"0000-0001-6594-2582","position":7,"is_corresponding":false},{"id":240411,"name":"Abrar A. Qureshi","orcid":"0000-0001-6157-6474","position":8,"is_corresponding":false},{"id":1150745,"name":"Moniyka Sachar","orcid":"0000-0002-1123-7850","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T01:17:29.050285Z","pmid":"37688423","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}