{"doi":"10.1111/ajd.12562","title":"Pemphigus, a pathomechanism of acantholysis","abstract":"<jats:title>Abstract</jats:title><jats:p>Autoantibodies to the desmosomal proteins desmoglein 1 and 3 cause pemphigus foliaceus and pemphigus vulgaris, which are characterised by keratinocyte dissociation (acantholysis) and intraepidermal blister formation. The passive transfer of pathogenic anti‐desmoglein antibodies induces blisters in mice <jats:italic>in vivo</jats:italic> and the loss of keratinocyte adhesion <jats:italic>in vitro</jats:italic>. The pathogenetic mechanisms of acantholysis due to anti‐desmoglein autoantibodies are not fully understood. However, recent studies have revealed that signalling‐dependent and signalling‐independent pathways are operative in the loss of cell adhesion. In this review, we focus on the pathomechanism of acantholysis due to autoantibodies to desmogleins and recent therapeutic approaches.</jats:p>","journal":"Australasian Journal of Dermatology","year":2017,"id":43383,"datarank":1.2294672843961385,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.8232597542308069,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.8232597542308069,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":14,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":206200,"name":"Takafumi Kadono","orcid":null,"position":1,"is_corresponding":false},{"id":206199,"name":"Masutaka Furue","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28211055","pmcid":null,"openalex_id":"https://openalex.org/W2588329979","authors":[],"funders":[],"total_grants":0,"fwci":1.1015,"citation_percentile":0.75728207,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":3},{"year":2020,"count":1},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":4},{"year":2025,"count":2}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fajd.12562","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/ajd.12562","host_type":"publisher"},{"url":"https://doi.org/10.1111/ajd.12562","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28211055","host_type":"repository"}],"fields_of_study":["Autoimmune Bullous Skin Diseases","Medicine","Biology","Acantholysis","Animals","Autoantibodies","Desmoglein 1","Desmoglein 3","Humans","MAP Kinase Signaling System","Pemphigus","p38 Mitogen-Activated Protein Kinases"],"mesh_terms":["Acantholysis","Animals","Autoantibodies","Humans","Pemphigus","MAP Kinase Signaling System","p38 Mitogen-Activated Protein Kinases","Desmoglein 1","Desmoglein 3"],"keywords":["Acantholysis","Desmoglein 1","Desmoglein 3","Pemphigus","Pemphigus foliaceus","Desmoglein","Medicine","Autoantibody","Pemphigus vulgaris","Desmosome","Keratinocyte","Immunology","Antibody","In vitro","Biology","Cell","p38 MAPK","Pathomechanism"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-14T22:51:31.864614Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}