{"doi":"10.1111/age.13250","title":"Genome‐wide scan for runs of homozygosity in Asian wild boars and Anqing six‐end‐white pigs","abstract":"<jats:title>Abstract</jats:title><jats:p>Inbreeding and loss of genetic diversity are serious problems in local Chinese pig breeds. Runs of homozygosity (ROHs) are contiguous lengths of homozygous genotypes that can provide information on inbreeding levels, mating schemes, selection pressure, and genetic events. The Anqing six‐end‐white (AQ) pig, an important autochthonous pig breed bred in the Anhui province of China, plays a key role in the local pig industry. In recent decades, AQ pigs have become a closed breed with a small population size in conservation farms, raising the issue of inbreeding decline. In this study, we used 10× resequencing to detect the whole genome of 24 AQ pigs and six Asian wild boars (AWBs). We used the Plink software to analyze the homozygosity of the genome and the distribution of ROHs in the genome based on the resequencing data. We obtained 935.04 Gb of raw data from the resequencing results and more than 45 822 239 SNPs. Additionally, we identified 28 702 ROHs. Compared with AWB, AQ pigs had higher ROH numbers, longer ROH rates, and higher <jats:italic>F</jats:italic><jats:sub>ROH</jats:sub> values, which revealed that artificial selection influenced ROH distribution and genome inbreeding level. A total of 307 and 205 ROH islands were identified in the AQ pigs and AWBs respectively. The genes of ROH islands in AQ pigs were mainly enriched in immune biological processes. Our findings provide a useful reference for developing breeding programs to maintain genetic diversity and germplasm resources in AQ pigs.</jats:p>","journal":"Animal Genetics","year":2022,"id":597251,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1530064,"name":"Ren Zhou","orcid":null,"position":1,"is_corresponding":false},{"id":1530065,"name":"Yuanlang Wang","orcid":null,"position":2,"is_corresponding":false},{"id":830037,"name":"Wei Zhang","orcid":"0000-0002-3575-6225","position":3,"is_corresponding":false},{"id":1530068,"name":"Xianrui Zheng","orcid":null,"position":4,"is_corresponding":false},{"id":1530069,"name":"Guiying Zhao","orcid":null,"position":5,"is_corresponding":false},{"id":118157,"name":"Xiaodong Zhang","orcid":"0000-0003-3260-870X","position":6,"is_corresponding":false},{"id":1526778,"name":"Zongjun Yin","orcid":null,"position":7,"is_corresponding":false},{"id":1530070,"name":"Yueyun Ding","orcid":null,"position":8,"is_corresponding":false},{"id":981509,"name":"Xudong Wu","orcid":"0000-0002-2881-954X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Genome‐wide scan for runs of homozygosity in Asian wild boars and Anqing six‐end‐white pigs","abstract":"<jats:title>Abstract</jats:title><jats:p>Inbreeding and loss of genetic diversity are serious problems in local Chinese pig breeds. Runs of homozygosity (ROHs) are contiguous lengths of homozygous genotypes that can provide information on inbreeding levels, mating schemes, selection pressure, and genetic events. The Anqing six‐end‐white (AQ) pig, an important autochthonous pig breed bred in the Anhui province of China, plays a key role in the local pig industry. In recent decades, AQ pigs have become a closed breed with a small population size in conservation farms, raising the issue of inbreeding decline. In this study, we used 10× resequencing to detect the whole genome of 24 AQ pigs and six Asian wild boars (AWBs). We used the Plink software to analyze the homozygosity of the genome and the distribution of ROHs in the genome based on the resequencing data. We obtained 935.04 Gb of raw data from the resequencing results and more than 45 822 239 SNPs. Additionally, we identified 28 702 ROHs. Compared with AWB, AQ pigs had higher ROH numbers, longer ROH rates, and higher <jats:italic>F</jats:italic><jats:sub>ROH</jats:sub> values, which revealed that artificial selection influenced ROH distribution and genome inbreeding level. A total of 307 and 205 ROH islands were identified in the AQ pigs and AWBs respectively. The genes of ROH islands in AQ pigs were mainly enriched in immune biological processes. Our findings provide a useful reference for developing breeding programs to maintain genetic diversity and germplasm resources in AQ pigs.</jats:p>","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":6,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36086874","pmcid":null,"openalex_id":"https://openalex.org/W4296250117","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"31972531","title":null}],"total_grants":1,"fwci":2.8573,"citation_percentile":0.91446105,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":5},{"year":2025,"count":2}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/age.13250","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/age.13250","host_type":"publisher"},{"url":"https://doi.org/10.1111/age.13250","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36086874","host_type":"repository"}],"fields_of_study":["Genetic and phenotypic traits in livestock","Cancer-related molecular mechanisms research","Genetic Mapping and Diversity in Plants and Animals"],"mesh_terms":["Animals","Genotype","Homozygote","Inbreeding","Swine","Genome","Polymorphism, Single Nucleotide","Sus scrofa"],"keywords":["Runs of Homozygosity","Biology","Inbreeding","Genetic diversity","Germplasm","Breed","Population","Genetics","Single-nucleotide polymorphism","Genotype","Gene","Demography","Agronomy"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.26231194.v1","title":"Additional file 1 of Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26747438","title":"Additional file 3 of Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26747438.v1","title":"Additional file 3 of Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26231317","title":"Additional file 2 of Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26231317.v1","title":"Additional file 2 of Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26231194","title":"Additional file 1 of Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink","publisher":"figshare","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T12:44:27.869082Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}