{"doi":"10.1111/add.16278","title":"Motivational interviewing and problem‐solving therapy intervention for patients on antiretroviral therapy for HIV in Tshwane, South Africa: A randomized controlled trial to assess the impact on alcohol consumption","abstract":"BACKGROUND AND AIMS: Reduction of alcohol consumption is important for people undergoing treatment for HIV. We tested the efficacy of a brief intervention for reducing the average volume of alcohol consumed among patients on HIV antiretroviral therapy (ART). DESIGN, SETTING AND PARTICIPANTS: This study used a two-arm multi-centre randomized controlled trial with follow-up to 6 months. Recruitment occurred between May 2016 and October 2017 at six ART clinics at public hospitals in Tshwane, South Africa. Participants were people living with HIV, mean age 40.8 years [standard deviation (SD) = 9.07], 57.5% female, and on average 6.9 years (SD = 3.62) on ART. At baseline (BL), the mean number of drinks consumed over the past 30 days was 25.2 (SD = 38.3). Of 756 eligible patients, 623 were enrolled. INTERVENTION: Participants were randomly assigned to a motivational interviewing (MI)/problem-solving therapy (PST) intervention arm (four modules of MI and PST delivered over two sessions by interventionists) or a treatment as usual (TAU) comparison arm. People assessing outcomes were masked to group assignment. MEASUREMENTS: The primary outcome was the number of standard drinks (15 ml pure alcohol) consumed during the past 30 days assessed at 6-month follow-up (6MFU). FINDINGS: Of the 305 participants randomized to MI/PST, 225 (74%) completed the intervention (all modules). At 6MFU, retention was 88% for the control and 83% for the intervention arm. In support of the hypothesis, an intention-to-treat-analysis for the primary outcome at 6MFU was -0.410 (95% confidence interval = -0.670 to -0.149) units lower on log scale in the intervention group than in the control group (P = 0.002), a 34% relative reduction in the number of drinks. Sensitivity analyses were undertaken for patients who had alcohol use disorders identification test (AUDIT) scores ≥ 8 at BL (n = 299). Findings were similar to those of the whole sample. CONCLUSIONS: In South Africa, a motivational interviewing/problem-solving therapy intervention significantly reduced drinking levels in HIV-infected patients on antiretroviral therapy at 6-month follow-up.","journal":"Addiction","year":2023,"id":333355,"datarank":0.5814938496268629,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.10478577507467092,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.10478577507467092,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":12,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9405,"is_data_producer":true,"deposit_databanks":{"PACTR":["PACTR201405000815100"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":503605,"name":"Bronwyn Myers","orcid":"0000-0003-0235-6716","position":1,"is_corresponding":false},{"id":1060663,"name":"Mukhethwa Londani","orcid":"0000-0002-7054-237X","position":2,"is_corresponding":false},{"id":297724,"name":"Paul A. Shuper","orcid":"0000-0001-9033-8598","position":3,"is_corresponding":false},{"id":1061164,"name":"Charl Janse van Rensburg","orcid":null,"position":4,"is_corresponding":false},{"id":1060664,"name":"Samuel Manda","orcid":"0000-0002-9672-3312","position":5,"is_corresponding":false},{"id":912504,"name":"Sebenzile Nkosi","orcid":"0000-0001-9901-1508","position":6,"is_corresponding":false},{"id":1061165,"name":"Connie T. Kekwaletswe","orcid":null,"position":7,"is_corresponding":false},{"id":416059,"name":"Judith A. Hahn","orcid":"0000-0002-2697-8264","position":8,"is_corresponding":false},{"id":244607,"name":"Jürgen Rehm","orcid":"0000-0001-5665-0385","position":9,"is_corresponding":false},{"id":725778,"name":"Katherine Sorsdahl","orcid":"0000-0002-5517-1697","position":10,"is_corresponding":false},{"id":1060665,"name":"Neo K. Morojele","orcid":"0000-0003-2891-2557","position":11,"is_corresponding":false},{"id":23213,"name":"Charles Parry","orcid":"0000-0001-9787-2785","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T01:09:39.719497Z","pmid":"37339811","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}