{"doi":"10.1111/add.15716","title":"Polygenic score for cigarette smoking is associated with ever electronic‐cigarette use in a college‐aged sample","abstract":"BACKGROUND AND AIMS: Electronic cigarette use has escalated rapidly in recent years, particularly among youth. Little is known about the genetic influences on e-cigarette use. This study aimed to determine whether genetic risk for regular use of combustible cigarettes or for number of cigarettes smoked per day confers risk for ever e-cigarette use or frequency of e-cigarette use. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: We used data from 9541 young adults from the Spit for Science longitudinal cohort study (2011-2019). Polygenic scores (PGS) of regular combustible cigarette use (PGS-RCU) and cigarettes per day (PGS-CPD) were constructed using summary statistics from the two largest available genome-wide association study (GWAS) meta-analysis of European ancestry and East Asian ancestry of combustible cigarette use and used to test whether the PGS of RCU or CPD predicted lifetime e-cigarette use and frequency of past 30-day e-cigarette use in a diverse sample of young adults of African (AFR), Admixed American (AMR), East Asian (EAS), European (EUR), and South Asian (SAS) ancestry. FINDINGS: ). There was no statistically significant association between PGS-CPD and lifetime e-cigarette use and neither the PGS-RCU nor the PGS-CPD were associated with frequency of e-cigarette use in the past 30 days in any of the subsamples. CONCLUSIONS: Genetic factors associated with regular combustible cigarette use appear to be associated with ever e-cigarette use in young adults. We did not find evidence for shared genetic factors influencing heaviness of use of combustible cigarettes and current e-cigarette use frequency.","journal":"Addiction","year":2021,"id":201723,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9455,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":526586,"name":"Elizabeth Do","orcid":"0000-0001-7845-7420","position":1,"is_corresponding":false},{"id":735766,"name":"K. Elizabeth","orcid":null,"position":2,"is_corresponding":false},{"id":665386,"name":"Jodi M. Gilman","orcid":"0000-0001-5180-6694","position":3,"is_corresponding":false},{"id":230726,"name":"Hermine H. Maes","orcid":"0000-0001-7489-2214","position":4,"is_corresponding":false},{"id":5271,"name":"Roseann E. Peterson","orcid":"0000-0001-6402-849X","position":5,"is_corresponding":false},{"id":498914,"name":"Elizabeth Prom‐Wormley","orcid":"0000-0001-9230-9723","position":6,"is_corresponding":false},{"id":287900,"name":"A. Eden Evins","orcid":"0000-0003-2071-9867","position":7,"is_corresponding":false},{"id":735295,"name":"Randi M. Schuster","orcid":"0000-0002-5710-9301","position":8,"is_corresponding":false},{"id":440954,"name":"Spit for Science Working Group","orcid":null,"position":9,"is_corresponding":false},{"id":526584,"name":"Megan Cooke","orcid":"0000-0001-9405-367X","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T23:50:56.394488Z","pmid":"34636095","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}