{"doi":"10.1111/adb.70000","title":"Increased white blood cell in young adults with family histories of alcohol and other substance use disorders","abstract":"Individuals with a family history of alcohol or other substance use disorders (FH+) are at increased risk for developing alcohol and other substance use disorders (AUD/SUD) compared to individuals with no such family histories (FH-). FH+ young adults have blunted stress reactivity, lower cognitive performance and altered frontal white matter microstructure compared to FH- controls. We hypothesized that family history of AUD/SUD disrupts neuroendocrine regulation of the immune system in FH+ individuals, resulting in altered blood immune cell composition, inflammation and neurocognitive alterations that, ultimately, increases risk for AUD/SUD and associated psychopathology. We examined white blood cell (WBC) parameters derived from complete blood counts in FH+ (n = 37) and FH- (n = 77) young adults without AUD/SUD to test if immune system dysregulation is present in FH+ individuals. The total WBC count, number of neutrophils and number of monocytes and associated systemic inflammatory response index (SIRI) were significantly increased in the FH+ group. Further, WBC, neutrophil, monocyte counts and SIRI values were all positively correlated with FH density (number of biological parents and grandparents with AUD/SUD). These novel data are the first to identify an association between family history of AUD/SUD and increased circulating leukocytes, which is likely indicative of immune dysregulation in FH+ young adults prior to onset of AUD/SUD. Additional studies are warranted to characterize the functional relevance of the observed immune cell composition in FH+ individuals, but the notion that inexpensive and widely available blood tests may help identify addiction risk could be transformative.","journal":"Addiction Biology","year":2024,"id":456799,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1282140,"name":"Nikki S. Phillips","orcid":null,"position":1,"is_corresponding":false},{"id":1282141,"name":"Dylan Nguyen","orcid":null,"position":2,"is_corresponding":false},{"id":1282142,"name":"Melanie S. Beehler","orcid":null,"position":3,"is_corresponding":false},{"id":1282143,"name":"Harrison S. Ballard","orcid":null,"position":4,"is_corresponding":false},{"id":781425,"name":"Andrea S. Vincent","orcid":"0000-0001-9693-5764","position":5,"is_corresponding":false},{"id":646578,"name":"William R. Lovallo","orcid":"0000-0002-8489-3509","position":6,"is_corresponding":false},{"id":227759,"name":"Peter Kochunov","orcid":"0000-0003-3656-4281","position":7,"is_corresponding":false},{"id":227758,"name":"L. Elliot Hong","orcid":"0000-0002-1472-2659","position":8,"is_corresponding":false},{"id":426570,"name":"Jason C. O’Connor","orcid":"0000-0002-5901-5640","position":9,"is_corresponding":false},{"id":335231,"name":"Steve W. Cole","orcid":"0000-0002-7168-8039","position":10,"is_corresponding":false},{"id":424297,"name":"Ashley Acheson","orcid":"0000-0002-3843-5726","position":11,"is_corresponding":false},{"id":625612,"name":"Mustafa N. Mithaiwala","orcid":"0000-0001-6478-683X","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T02:03:32.516678Z","pmid":"39558659","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}