{"doi":"10.1111/adb.13398","title":"Global, interhemispheric and intrahemispheric functional connection patterns in male adults with alcohol use disorder","abstract":"<jats:title>Abstract</jats:title><jats:p>A growing body of evidence indicates the existence of abnormal local and long‐range functional connection patterns in patients with alcohol use disorder (AUD). However, it has yet to be established whether AUD is associated with abnormal interhemispheric and intrahemispheric functional connection patterns. In the present study, we analysed resting‐state functional magnetic resonance imaging data from 55 individuals with AUD and 32 healthy nonalcohol users. For each subject, whole‐brain functional connectivity density (FCD) was decomposed into ipsilateral and contralateral parts. Correlation analysis was performed between abnormal FCD and a range of clinical measurements in the AUD group. Compared with healthy controls, the AUD group exhibited a reduced global FCD in the anterior and middle cingulate gyri, prefrontal cortex and thalamus, along with an enhanced global FCD in the temporal, parietal and occipital cortices. Abnormal interhemispheric and intrahemispheric FCD patterns were also detected in the AUD group. Furthermore, abnormal global, contralateral and ipsilateral FCD data were correlated with the mean amount of pure alcohol and the severity of alcohol addiction in the AUD group. Collectively, our findings indicate that global, interhemispheric and intrahemispheric FCD may represent a robust method to detect abnormal functional connection patterns in AUD; this may help us to identify the neural substrates and therapeutic targets of AUD.</jats:p>","journal":"Addiction Biology","year":2024,"id":623458,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":703892,"name":"Weijian Wang","orcid":"0000-0001-9691-6395","position":1,"is_corresponding":false},{"id":1611260,"name":"Yimeng Kang","orcid":null,"position":2,"is_corresponding":false},{"id":554567,"name":"Xiaoyu Niu","orcid":"0000-0002-6412-7348","position":3,"is_corresponding":false},{"id":1611262,"name":"Zanxia Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":769841,"name":"Shujian Li","orcid":null,"position":5,"is_corresponding":false},{"id":477095,"name":"Shaoqiang Han","orcid":"0000-0001-7331-0315","position":6,"is_corresponding":false},{"id":1316028,"name":"Jingliang Cheng","orcid":"0000-0003-4223-5011","position":7,"is_corresponding":false},{"id":449738,"name":"Yong Zhang","orcid":"0000-0003-4892-6614","position":8,"is_corresponding":false},{"id":1611259,"name":"Yarui Wei","orcid":"0000-0002-4264-6374","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Global, interhemispheric and intrahemispheric functional connection patterns in male adults with alcohol use disorder","abstract":"<jats:title>Abstract</jats:title><jats:p>A growing body of evidence indicates the existence of abnormal local and long‐range functional connection patterns in patients with alcohol use disorder (AUD). However, it has yet to be established whether AUD is associated with abnormal interhemispheric and intrahemispheric functional connection patterns. In the present study, we analysed resting‐state functional magnetic resonance imaging data from 55 individuals with AUD and 32 healthy nonalcohol users. For each subject, whole‐brain functional connectivity density (FCD) was decomposed into ipsilateral and contralateral parts. Correlation analysis was performed between abnormal FCD and a range of clinical measurements in the AUD group. Compared with healthy controls, the AUD group exhibited a reduced global FCD in the anterior and middle cingulate gyri, prefrontal cortex and thalamus, along with an enhanced global FCD in the temporal, parietal and occipital cortices. Abnormal interhemispheric and intrahemispheric FCD patterns were also detected in the AUD group. Furthermore, abnormal global, contralateral and ipsilateral FCD data were correlated with the mean amount of pure alcohol and the severity of alcohol addiction in the AUD group. Collectively, our findings indicate that global, interhemispheric and intrahemispheric FCD may represent a robust method to detect abnormal functional connection patterns in AUD; this may help us to identify the neural substrates and therapeutic targets of AUD.</jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38899438","pmcid":"PMC11187543","openalex_id":"https://openalex.org/W4399873155","authors":[],"funders":[{"funder_name":"National Key Research and Development Program of China","grant_id":"SQ2018YFC130095","title":null},{"funder_name":"Henan Provincial Science and Technology Research Project","grant_id":"172102310391","title":null},{"funder_name":"Henan Province Key Research and Development and Promotion of Special Projects","grant_id":"212102310699","title":null},{"funder_name":"Joint Construction Project of Health Commission of Henan Province","grant_id":"LHGJ20220404","title":null},{"funder_name":"Support Project of Henan Province","grant_id":"212102310712","title":null},{"funder_name":"Beijing Health Alliance Charitable Foundation","grant_id":"HN-20201017-004","title":null},{"funder_name":"Key Research Program of the Higher Education Institutions of Henan Province","grant_id":"23A320004","title":null},{"funder_name":"Joint Construction Project of Health Commission of Henan Province","grant_id":"LHGJ20200384","title":null},{"funder_name":"Key Research and Generalization Special Project of Henan Province","grant_id":"232102310142","title":null},{"funder_name":"Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University","grant_id":"QNCXTD2023007","title":null},{"funder_name":"Key Research and Development and Promotion","grant_id":"","title":null},{"funder_name":"Key Research and Development and Promotion","grant_id":"","title":null}],"total_grants":12,"fwci":0.4786,"citation_percentile":0.58519464,"influential_citations":0,"citation_trend":[{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/adb.13398","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/adb.13398","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/adb.13398","host_type":"publisher"},{"url":"https://doi.org/10.1111/adb.13398","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38899438","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11187543","host_type":"repository"},{"url":"https://osf.io/2dzcj","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11187543/pdf/ADB-29-e13398.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11187543","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11187543?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Functional Brain Connectivity Studies","Advanced Neuroimaging Techniques and Applications","Neural dynamics and brain function","Humans","Male","Alcoholism","Magnetic Resonance Imaging","Adult","Brain","Middle Aged","Prefrontal Cortex","Thalamus","Case-Control Studies","Gyrus Cinguli","Brain Mapping","Young Adult"],"mesh_terms":["Adult","Alcoholism","Brain","Brain Mapping","Gyrus Cinguli","Humans","Magnetic Resonance Imaging","Male","Middle Aged","Thalamus","Case-Control Studies","Prefrontal Cortex","Young Adult"],"keywords":["Alcohol use disorder","Functional magnetic resonance imaging","Functional connectivity","Psychology","Neuroscience","Cingulate cortex","Anterior cingulate cortex","Alcohol","Medicine","Central nervous system","Biology","Cognition","Functional Connectivity Degree","Resting‐state Functional Magnetic Resonance Imaging","Interhemisphere","Intrahemisphere","Addiction Remission"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T23:53:42.965116Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}