{"doi":"10.1111/adb.12238","title":"Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines","abstract":null,"journal":"Addiction Biology","year":2016,"id":625380,"datarank":0.5775221402565088,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"self_citation_contribution":0.5775221402565088,"citation_network_contribution":0.0,"self_endowment_contribution":0.5775221402565088,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1617289,"name":"Natalie S. McGuier","orcid":null,"position":1,"is_corresponding":false},{"id":369797,"name":"Justin T. Gass","orcid":"0000-0002-6829-6261","position":2,"is_corresponding":false},{"id":199330,"name":"William C. Griffin","orcid":null,"position":3,"is_corresponding":false},{"id":361356,"name":"Lauren E. Ball","orcid":"0000-0001-6780-1679","position":4,"is_corresponding":false},{"id":414400,"name":"Patrick J. Mulholland","orcid":"0000-0003-0780-5971","position":5,"is_corresponding":false},{"id":473965,"name":"Joachim D. Uys","orcid":"0000-0002-4213-9356","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines","abstract":"Alcohol use disorder is a chronic relapsing brain disease characterized by the loss of ability to control alcohol (ethanol) intake despite knowledge of detrimental health or personal consequences. Clinical and pre-clinical models provide strong evidence for chronic ethanol-associated alterations in glutamatergic signaling and impaired synaptic plasticity in the nucleus accumbens (NAc). However, the neural mechanisms that contribute to aberrant glutamatergic signaling in ethanol-dependent individuals in this critical brain structure remain unknown. Using an unbiased proteomic approach, we investigated the effects of chronic intermittent ethanol (CIE) exposure on neuroadaptations in postsynaptic density (PSD)-enriched proteins in the NAc of ethanol-dependent mice. Compared with controls, CIE exposure significantly changed expression levels of 50 proteins in the PSD-enriched fraction. Systems biology and functional annotation analyses demonstrated that the dysregulated proteins are expressed at tetrapartite synapses and critically regulate cellular morphology. To confirm this latter finding, the density and morphology of dendritic spines were examined in the NAc core of ethanol-dependent mice. We found that CIE exposure and withdrawal differentially altered dendrite diameter and dendritic spine density and morphology. Through the use of quantitative proteomics and functional annotation, these series of experiments demonstrate that ethanol dependence produces neuroadaptations in proteins that modify dendritic spine morphology. In addition, these studies identified novel PSD-related proteins that contribute to the neurobiological mechanisms of ethanol dependence that drive maladaptive structural plasticity of NAc neurons.","is_dataset_classified":null,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25787124","pmcid":"PMC4573771","openalex_id":"https://openalex.org/W1589305524","authors":[],"funders":[{"funder_name":"NIH","grant_id":"RR024485","title":null},{"funder_name":"NIH","grant_id":"GM103542","title":null},{"funder_name":"NIH","grant_id":"AA020537","title":null},{"funder_name":"NIH","grant_id":"AA010761","title":null},{"funder_name":"NIH","grant_id":"AA020930","title":null},{"funder_name":"NIH","grant_id":"AA021618","title":null},{"funder_name":"SC COBRE in Oxidants, Redox Balance, and Stress Signaling","grant_id":"P20 GM103542","title":null},{"funder_name":"NIAAA NIH HHS","grant_id":"R00 AA020537","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM123456","title":null},{"funder_name":"NIH HHS","grant_id":"S10 OD010731","title":null},{"funder_name":"NIAAA NIH HHS","grant_id":"K99 AA020537","title":null},{"funder_name":"NIAAA NIH HHS","grant_id":"F31 AA021618","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"P20 RR024485","title":null},{"funder_name":"NIAAA NIH HHS","grant_id":"P50 AA010761","title":null},{"funder_name":"PHS HHS","grant_id":"S10 D010731","title":null},{"funder_name":"NIAAA NIH HHS","grant_id":"U01 AA020930","title":null},{"funder_name":"Office of the Provost","grant_id":"","title":null}],"total_grants":17,"fwci":2.1954,"citation_percentile":0.86612404,"influential_citations":0,"citation_trend":[{"year":2015,"count":4},{"year":2016,"count":3},{"year":2017,"count":6},{"year":2018,"count":4},{"year":2019,"count":7},{"year":2020,"count":4},{"year":2021,"count":4},{"year":2022,"count":2},{"year":2023,"count":5},{"year":2024,"count":2},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"green","license":"http://doi.wiley.com/10.1002/tdm_license_1","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4573771","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4573771","host_type":"repository"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fadb.12238","host_type":"publisher"},{"url":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/adb.12238/fullpdf","host_type":"publisher"},{"url":"https://doi.org/10.1111/adb.12238","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25787124","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Neurotransmitter Receptor Influence on Behavior","Mitochondrial Function and Pathology","Alcoholism","Animals","Blotting, Western","Central Nervous System Depressants","Chromatography, Liquid","Dendritic Spines","Disease Models, Animal","Ethanol","Male","Mice","Nucleus Accumbens","Post-Synaptic Density","Proteome","Substance Withdrawal Syndrome","Tandem Mass Spectrometry"],"mesh_terms":["Ethanol","Alcoholism","Animals","Central Nervous System Depressants","Chromatography, Liquid","Disease Models, Animal","Male","Nucleus Accumbens","Substance Withdrawal Syndrome","Blotting, Western","Proteome","Dendritic Spines","Mice","Tandem Mass Spectrometry","Post-Synaptic Density"],"keywords":["Dendritic spine","Nucleus accumbens","Postsynaptic density","Glutamatergic","Proteome","Medium spiny neuron","Synaptic plasticity","Postsynaptic potential","Neuroplasticity","Neuroscience","Long-term potentiation","Scaffold protein","Biology","Glutamate receptor","Cell biology","Basal ganglia","Signal transduction","Receptor","Biochemistry","Central nervous system","Proteomics","Cellular morphology","Dendritic Spines","Structural Plasticity","Chronic Intermittent Ethanol Exposure"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"uniprot"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T06:37:25.495324Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}