{"doi":"10.1111/acps.12328","title":"Incident subjective memory complaints and the risk of subsequent dementia","abstract":"<jats:sec><jats:title>Objective</jats:title><jats:p>In this study, we aimed to analyze the association between new—<jats:italic>incident</jats:italic>—subjective memory complaints (<jats:styled-content style=\"fixed-case\">SMC</jats:styled-content>) and risk of subsequent dementia in a general population sample aged 75+ years.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>Data were derived from follow‐up (<jats:styled-content style=\"fixed-case\">FUP</jats:styled-content>) waves I‐V of the population‐based Leipzig Longitudinal Study of the Aged (<jats:styled-content style=\"fixed-case\">LEILA</jats:styled-content>75+). We used the Kaplan–Meier survival method to estimate dementia‐free survival times of individuals with and without incident <jats:styled-content style=\"fixed-case\">SMC</jats:styled-content> and multivariable Cox proportional hazards regression to assess the association between incident <jats:styled-content style=\"fixed-case\">SMC</jats:styled-content> and risk of subsequent dementia, controlled for covariates.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 443 non‐demented individuals, 58 (13.1%) developed dementia during a subsequent 5.4‐year follow‐up period. Participants with incident <jats:styled-content style=\"fixed-case\">SMC</jats:styled-content> showed a significantly higher progression to dementia (18.5% vs. 10.0%; <jats:italic>P </jats:italic>=<jats:italic> </jats:italic>0.010) and a significantly shorter mean dementia‐free survival time than those without (6.2 vs. 6.8 years; <jats:italic>P </jats:italic>=<jats:italic> </jats:italic>0.008). The association between incident <jats:styled-content style=\"fixed-case\">SMC</jats:styled-content> and risk of subsequent dementia remained significant in the multivariable Cox analysis (adjusted hazard ratio = 1.8; <jats:italic>P</jats:italic> = 0.028).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings suggest higher progression to dementia and shorter dementia‐free survival in older individuals with incident <jats:styled-content style=\"fixed-case\">SMC</jats:styled-content>. These findings support the notion that such subjective complaints should be taken seriously in clinical practice as possible early indicators of incipient dementia.</jats:p></jats:sec>","journal":"Acta Psychiatrica Scandinavica","year":2015,"id":623355,"datarank":0.6284482113039639,"base_score":4.189654742026425,"endowment":4.189654742026425,"self_citation_contribution":0.6284482113039639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6284482113039639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1610938,"name":"M. Luppa","orcid":null,"position":1,"is_corresponding":false},{"id":1610939,"name":"H. Matschinger","orcid":null,"position":2,"is_corresponding":false},{"id":1234067,"name":"F. Jessen","orcid":"0000-0002-9537-5002","position":3,"is_corresponding":false},{"id":1610940,"name":"M. C. Angermeyer","orcid":null,"position":4,"is_corresponding":false},{"id":1610941,"name":"S. G. Riedel‐Heller","orcid":null,"position":5,"is_corresponding":false},{"id":1610937,"name":"T. Luck","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Incident subjective memory complaints and the risk of subsequent dementia","abstract":"<jats:sec><jats:title>Objective</jats:title><jats:p>In this study, we aimed to analyze the association between new—<jats:italic>incident</jats:italic>—subjective memory complaints (<jats:styled-content style=\"fixed-case\">SMC</jats:styled-content>) and risk of subsequent dementia in a general population sample aged 75+ years.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>Data were derived from follow‐up (<jats:styled-content style=\"fixed-case\">FUP</jats:styled-content>) waves I‐V of the population‐based Leipzig Longitudinal Study of the Aged (<jats:styled-content style=\"fixed-case\">LEILA</jats:styled-content>75+). We used the Kaplan–Meier survival method to estimate dementia‐free survival times of individuals with and without incident <jats:styled-content style=\"fixed-case\">SMC</jats:styled-content> and multivariable Cox proportional hazards regression to assess the association between incident <jats:styled-content style=\"fixed-case\">SMC</jats:styled-content> and risk of subsequent dementia, controlled for covariates.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 443 non‐demented individuals, 58 (13.1%) developed dementia during a subsequent 5.4‐year follow‐up period. Participants with incident <jats:styled-content style=\"fixed-case\">SMC</jats:styled-content> showed a significantly higher progression to dementia (18.5% vs. 10.0%; <jats:italic>P </jats:italic>=<jats:italic> </jats:italic>0.010) and a significantly shorter mean dementia‐free survival time than those without (6.2 vs. 6.8 years; <jats:italic>P </jats:italic>=<jats:italic> </jats:italic>0.008). The association between incident <jats:styled-content style=\"fixed-case\">SMC</jats:styled-content> and risk of subsequent dementia remained significant in the multivariable Cox analysis (adjusted hazard ratio = 1.8; <jats:italic>P</jats:italic> = 0.028).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings suggest higher progression to dementia and shorter dementia‐free survival in older individuals with incident <jats:styled-content style=\"fixed-case\">SMC</jats:styled-content>. These findings support the notion that such subjective complaints should be taken seriously in clinical practice as possible early indicators of incipient dementia.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":4.189654742026425,"endowment":4.189654742026425,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25201166","pmcid":null,"openalex_id":"https://openalex.org/W2158317759","authors":[],"funders":[{"funder_name":"Interdisciplinary Centre for Clinical Research Leipzig","grant_id":"project C07","title":null}],"total_grants":1,"fwci":3.7478,"citation_percentile":0.9376192,"influential_citations":0,"citation_trend":[{"year":2015,"count":6},{"year":2016,"count":8},{"year":2017,"count":5},{"year":2018,"count":6},{"year":2019,"count":6},{"year":2020,"count":11},{"year":2021,"count":9},{"year":2022,"count":4},{"year":2023,"count":5},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Facps.12328","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/acps.12328","host_type":"publisher"},{"url":"https://doi.org/10.1111/acps.12328","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25201166","host_type":"repository"},{"url":"https://pub.dzne.de/record/137825","host_type":"repository"}],"fields_of_study":["Dementia and Cognitive Impairment Research","Alzheimer's disease research and treatments","Elder Abuse and Neglect"],"mesh_terms":["Aged","Aged, 80 and over","Dementia","Female","Humans","Longitudinal Studies","Male","Memory Disorders","Disease Progression","Kaplan-Meier Estimate"],"keywords":["Dementia","Proportional hazards model","Hazard ratio","Medicine","Population","Longitudinal study","Gerontology","Internal medicine","Psychology","Confidence interval","Pathology","Disease","epidemiology","early intervention","Outcome","Old-age"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T23:25:43.835454Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}