{"doi":"10.1111/acer.15461","title":"Alcohol use and cannabis craving in daily life: Sex differences and associations among young adults","abstract":"BACKGROUND: Alcohol and cannabis are commonly used together by young adults. With frequent pairings, use of one substance may become a conditioned cue for use of a second, commonly co-used substance. Although this has been examined for alcohol and cannabis in laboratory conditions and with remote monitoring, no research has examined whether pharmacologically induced cross-substance craving occurs in naturalistic conditions. METHODS: In a sample of 63 frequent cannabis-using young adults (54% female) who completed 2 weeks of ecological momentary assessment, we tested whether alcohol use was associated with stronger in-the-moment cannabis craving. We also examined whether sex moderated this association and whether cannabis craving was stronger at higher levels of alcohol consumption. RESULTS: Although alcohol use and cannabis craving were not significantly associated at the momentary level, there was evidence that this relation significantly differed by sex. Among female participants, there was a negative association between alcohol use since the last prompt and momentary cannabis craving (b = -0.33, SE = 0.14, p = 0.02), while the association among male participants was positive (b = 0.32, SE = 0.13, p = 0.01). Similarly, alcohol quantity was negatively associated with cannabis craving at the momentary level for female participants (b = -0.10, SE = 0.04, p = 0.009) but was not significantly associated for male participants (b = 0.05, SE = 0.04, p = 0.18). CONCLUSIONS: Alcohol may enhance cannabis craving among male individuals but reduce desire for cannabis among female individuals. This may point to differing functions of co-use by sex, highlighting a need for research to elucidate the mechanisms underlying this increasingly common pattern of substance use.","journal":"Alcohol Clinical and Experimental Research","year":2024,"id":479167,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9593,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":428037,"name":"Nolan E. Ramer","orcid":"0000-0001-9032-3572","position":1,"is_corresponding":false},{"id":268689,"name":"Lindsay M. Squeglia","orcid":"0000-0001-5994-6894","position":2,"is_corresponding":false},{"id":963407,"name":"Kathryn S. Gex","orcid":"0000-0001-7458-6508","position":3,"is_corresponding":false},{"id":698478,"name":"Aimee L. McRae‐Clark","orcid":"0000-0002-9774-318X","position":4,"is_corresponding":false},{"id":388499,"name":"Sherry A. McKee","orcid":"0000-0001-8185-9201","position":5,"is_corresponding":false},{"id":413473,"name":"Walter Roberts","orcid":"0000-0001-6817-884X","position":6,"is_corresponding":false},{"id":350609,"name":"Kevin M. Gray","orcid":"0000-0003-4503-7395","position":7,"is_corresponding":false},{"id":447507,"name":"Nathaniel L. Baker","orcid":"0000-0003-3313-1579","position":8,"is_corresponding":false},{"id":268688,"name":"Rachel L. Tomko","orcid":"0000-0002-6961-4399","position":9,"is_corresponding":false},{"id":1122538,"name":"Christal N. Davis","orcid":"0000-0003-3974-5598","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T02:06:50.355747Z","pmid":"39579151","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}