{"doi":"10.1111/acer.15259","title":"Neural correlates of drinking reduction during a clinical trial of cognitive behavioral therapy for alcohol use disorder","abstract":"BACKGROUND: Cognitive behavioral therapy (CBT) is an effective treatment for alcohol use disorder (AUD). We hypothesized that the dorsolateral prefrontal cortex (DLPFC), a region implicated in cognitive control and goal-directed behavior, plays a role in behavior change during CBT by facilitating the regulation of craving (ROC). METHODS: Treatment-seeking participants with AUD (N = 22) underwent functional magnetic resonance imaging (fMRI) scanning both before and after a 12-week, single-arm trial of CBT, using an ROC task that was previously shown to engage the DLPFC. RESULTS: We found that both the percentage of heavy drinking days (PHDD) and the overall self-reported alcohol craving measured during the ROC task were significantly reduced from pre- to post-CBT. However, we did not find significant changes over time in either the ability to regulate craving or regulation-related activity in any brain region. We found a significant 3-way interaction between the effects of cue-induced craving, cue-induced brain activity and timepoint of assessment (pre- or post-CBT) on PHDD in the left DLPFC. Follow-up analysis showed that cue-induced craving was associated with cue-induced activity in the left DLPFC among participants who ceased heavy drinking during CBT, both at pre-CBT and post-CBT timepoints. No such associations were present at either timepoint among participants who continued to drink heavily. CONCLUSIONS: These results suggest that patients in whom DLPFC functioning is more strongly related to cue-induced craving may preferentially respond to CBT.","journal":"Alcohol Clinical and Experimental Research","year":2024,"id":464602,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9562,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":259381,"name":"A. Benjamin Srivastava","orcid":"0000-0001-9358-7506","position":1,"is_corresponding":false},{"id":602445,"name":"Juan Sanchez‐Peña","orcid":null,"position":2,"is_corresponding":false},{"id":487477,"name":"Jessica K. Lee","orcid":null,"position":3,"is_corresponding":false},{"id":259391,"name":"Andrew T. Drysdale","orcid":"0000-0002-6824-9190","position":4,"is_corresponding":false},{"id":522411,"name":"John J. Mariani","orcid":"0000-0002-9535-7744","position":5,"is_corresponding":false},{"id":693962,"name":"Kevin N. Ochsner","orcid":"0000-0001-8532-2129","position":6,"is_corresponding":false},{"id":795487,"name":"Jon Morgenstern","orcid":null,"position":7,"is_corresponding":false},{"id":259387,"name":"Gaurav H. Patel","orcid":"0000-0003-0028-2098","position":8,"is_corresponding":false},{"id":522412,"name":"Frances R. Levin","orcid":"0000-0003-4209-1329","position":9,"is_corresponding":false},{"id":722619,"name":"Nasir H. Naqvi","orcid":null,"position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-19T02:04:42.082401Z","pmid":"38225187","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}