{"doi":"10.1111/acel.70277","title":"A Nuclear Hormone Receptor <i>nhr‐76</i> Induces Age‐Dependent Chemotaxis Decline in <i>C. elegans</i>","abstract":"A decline in food-searching behavior of post-reproductive animals can benefit the population and possibly be programmed by the genome despite its detrimental effect on an individual. We investigated the genetic program of age-dependent decline in chemotaxis behavior toward an odorant secreted from bacterial food in C. elegans. Through a novel forward genetic screen, we identified the gene encoding a nuclear hormone receptor, nhr-76, whose mutants ameliorate the age-dependent chemotaxis decline. We found that NHR-76 downregulates odorant receptor expression during aging in a ligand-binding-domain-dependent manner. Since NHR-76 expression and localization remain unchanged with age, its activity may be modulated through the ligand-binding domain, leading to age-dependent chemotaxis decline. Our findings imply that post-reproductive behavioral decline can be genetically programmed.","journal":"Aging Cell","year":2025,"id":578869,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9588,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":416551,"name":"Kentaro Noma","orcid":"0000-0002-6487-8037","position":1,"is_corresponding":false},{"id":1193742,"name":"Rikuou Yokosawa","orcid":null,"position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T02:58:24.957414Z","pmid":"41128441","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}