{"doi":"10.1111/acel.70152","title":"Even at 100+: Acute Exercise Modulates Inflammatory Pathways in Centenarians","abstract":"Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100-104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan, humans retain molecular responsiveness to exercise, with modulation of inflammation-related pathways.","journal":"Aging Cell","year":2025,"id":545377,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1436171,"name":"Lidia B. Alejo","orcid":"0000-0001-6347-1369","position":1,"is_corresponding":false},{"id":932058,"name":"Inmaculada Pérez‐Prieto","orcid":"0000-0002-1141-9187","position":2,"is_corresponding":false},{"id":1416996,"name":"Pedro Carrera‐Bastos","orcid":"0000-0002-4218-1300","position":3,"is_corresponding":false},{"id":1436172,"name":"María Jesús Ruiz Muñoz","orcid":"0000-0003-1486-0557","position":4,"is_corresponding":false},{"id":1436173,"name":"Itziar Págola Aldazabal","orcid":"0000-0002-8562-2700","position":5,"is_corresponding":false},{"id":1436174,"name":"David Barranco‐Gil","orcid":"0000-0002-4869-5900","position":6,"is_corresponding":false},{"id":1025822,"name":"Alejandro Santos‐Lozano","orcid":"0000-0002-2309-3583","position":7,"is_corresponding":false},{"id":1436175,"name":"Gabriel Rodríguez‐Romo","orcid":"0000-0003-3111-6340","position":8,"is_corresponding":false},{"id":1436176,"name":"Natalia Yanguas‐Casás","orcid":"0000-0003-4368-0176","position":9,"is_corresponding":false},{"id":235321,"name":"Shlomit Radom‐Aizik","orcid":"0009-0004-4023-7026","position":10,"is_corresponding":false},{"id":77497,"name":"Alejandro Lucia","orcid":null,"position":11,"is_corresponding":false},{"id":1293337,"name":"Carmen Fiuza‐Luces","orcid":"0000-0001-8131-7007","position":12,"is_corresponding":false},{"id":773765,"name":"Abel Plaza‐Florido","orcid":"0000-0002-5374-3129","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T02:53:23.001995Z","pmid":"40874701","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}