{"doi":"10.1111/acel.14252","title":"Casual associations between brain structure and sarcopenia: A large‐scale genetic correlation and mendelian randomization study","abstract":"<jats:title>Abstract</jats:title><jats:p>Sarcopenia presenting a critical challenge in population‐aging healthcare. The elucidation of the interplay between brain structure and sarcopenia necessitates further research. The aim of this study is to explore the casual association between brain structure and sarcopenia. Linkage disequilibrium score regression (LDSC) was conducted to estimate the genetic correlations; MR was then performed to explore the causal relationship between Brain imaging‐derived phenotypes (BIDPs) and three sarcopenia‐related traits: handgrip strength, walking pace, and appendicular lean mass (ALM). The main analyses were conducted using the inverse‐variance weighted method. Moreover, weighted median and MR–Egger were conducted as sensitivity analyses. Genetic association between 6.41% of BIDPs and ALM was observed, and 4.68% of BIDPs exhibited causal MR association with handgrip strength, 2.11% of BIDPs were causally associated with walking pace, and 2.04% of BIDPs showed causal association with ALM. Volume of ventromedial hypothalamus was associated with increased odds of handgrip strength (OR: 1.18, 95% CI: 1.02 to 1.37) and ALM (OR: 1.05, 95% CI: 1.01 to 1.09). Mean thickness of G‐pariet‐inf‐Angular was associated with decreased odds of handgrip strength (OR: 0.83, 95% CI: 0.70 to 0.97) and walking pace (OR: 0.97, 95% CI: 0.93 to 0.99). As part of the brain structure forward causally influences sarcopenia, which may provide new perspectives for the prevention of sarcopenia and offer valuable insights for further research on the brain‐muscle axis.</jats:p>","journal":"Aging Cell","year":2024,"id":622005,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1341160,"name":"Wenqing Xie","orcid":"0000-0001-9810-7372","position":1,"is_corresponding":false},{"id":1046490,"name":"Bin Li","orcid":"0000-0002-8442-0154","position":2,"is_corresponding":false},{"id":1606470,"name":"Guihu Zhao","orcid":null,"position":3,"is_corresponding":false},{"id":1024555,"name":"Jinchen Li","orcid":"0000-0003-3335-9303","position":4,"is_corresponding":false},{"id":980708,"name":"Wenfeng Xiao","orcid":"0000-0002-4657-8698","position":5,"is_corresponding":false},{"id":317528,"name":"Yusheng Li","orcid":"0009-0006-7414-9053","position":6,"is_corresponding":false},{"id":640623,"name":"Guang Yang","orcid":"0000-0001-9198-3556","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Casual associations between brain structure and sarcopenia: A large‐scale genetic correlation and mendelian randomization study","abstract":"<jats:title>Abstract</jats:title><jats:p>Sarcopenia presenting a critical challenge in population‐aging healthcare. The elucidation of the interplay between brain structure and sarcopenia necessitates further research. The aim of this study is to explore the casual association between brain structure and sarcopenia. Linkage disequilibrium score regression (LDSC) was conducted to estimate the genetic correlations; MR was then performed to explore the causal relationship between Brain imaging‐derived phenotypes (BIDPs) and three sarcopenia‐related traits: handgrip strength, walking pace, and appendicular lean mass (ALM). The main analyses were conducted using the inverse‐variance weighted method. Moreover, weighted median and MR–Egger were conducted as sensitivity analyses. Genetic association between 6.41% of BIDPs and ALM was observed, and 4.68% of BIDPs exhibited causal MR association with handgrip strength, 2.11% of BIDPs were causally associated with walking pace, and 2.04% of BIDPs showed causal association with ALM. Volume of ventromedial hypothalamus was associated with increased odds of handgrip strength (OR: 1.18, 95% CI: 1.02 to 1.37) and ALM (OR: 1.05, 95% CI: 1.01 to 1.09). Mean thickness of G‐pariet‐inf‐Angular was associated with decreased odds of handgrip strength (OR: 0.83, 95% CI: 0.70 to 0.97) and walking pace (OR: 0.97, 95% CI: 0.93 to 0.99). As part of the brain structure forward causally influences sarcopenia, which may provide new perspectives for the prevention of sarcopenia and offer valuable insights for further research on the brain‐muscle axis.</jats:p>","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38881464","pmcid":"PMC11464103","openalex_id":"https://openalex.org/W4399749733","authors":[],"funders":[{"funder_name":"National Key Research and Development Program of China","grant_id":"2021YFC2502100","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2023YFC3603404","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2019YFA0111900","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82072506","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82272611","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"92268115","title":null},{"funder_name":"The Independent Exploration and Innovation Project for Postgraduate Students of Central South University","grant_id":"2024ZZTS0163","title":null},{"funder_name":"National Natural Science Foundation of Hunan Province","grant_id":"2023JJ30949","title":null},{"funder_name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital","grant_id":"2021LNJJ05","title":null},{"funder_name":"Provincial Natural Science Foundation of Hunan","grant_id":"2020JJ3060","title":null},{"funder_name":"Provincial Clinical Medical Technology Innovation Project of Hunan","grant_id":"2020SK53709","title":null},{"funder_name":"Hunan Young Talents of Science and Technology","grant_id":"2021RC3025","title":null},{"funder_name":"Hunan Provincial Science Fund for Distinguished Young Scholars","grant_id":"2024JJ2089","title":null},{"funder_name":"The Hunan Provincial Innovation Foundation for Postgraduate","grant_id":"CX20230308","title":null},{"funder_name":"The Hunan Provincial Innovation Foundation for Postgraduate","grant_id":"CX20230312","title":null},{"funder_name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital","grant_id":"2021KFJJ02","title":null},{"funder_name":"Provincial Clinical Medical Technology Innovation Project of Hunan","grant_id":"2023SK2024","title":null}],"total_grants":17,"fwci":1.6823,"citation_percentile":0.84175811,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.14252","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.14252","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.14252","host_type":"publisher"},{"url":"https://doi.org/10.1111/acel.14252","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38881464","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11464103","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11464103/pdf/ACEL-23-e14252.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11464103","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11464103?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Nutrition and Health in Aging","Body Composition Measurement Techniques","Muscle Physiology and Disorders"],"mesh_terms":["Brain","Female","Humans","Male","Phenotype","Hand Strength","Sarcopenia","Mendelian Randomization Analysis"],"keywords":["Sarcopenia","Mendelian randomization","Genome-wide association study","Population","Odds ratio","Physical medicine and rehabilitation","Biology","Internal medicine","Medicine","Genetics","Single-nucleotide polymorphism","Genotype","Genetic variants","Environmental health","Brain","Ldsc","Bidps"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T17:47:39.610780Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}