{"doi":"10.1111/acel.13540","title":"Association between IGF‐1 levels ranges and all‐cause mortality: A meta‐analysis","abstract":"The association between IGF-1 levels and mortality in humans is complex with low levels being associated with both low and high mortality. The present meta-analysis investigates this complex relationship between IGF-1 and all-cause mortality in prospective cohort studies. A systematic literature search was conducted in PubMed/MEDLINE, Scopus, and Cochrane Library up to September 2019. Published studies were eligible for the meta-analysis if they had a prospective cohort design, a hazard ratio (HR) and 95% confidence interval (CI) for two or more categories of IGF-1 and were conducted among adults. A random-effects model with a restricted maximum likelihood heterogeneity variance estimator was used to find combined HRs for all-cause mortality. Nineteen studies involving 30,876 participants were included. Meta-analysis of the 19 eligible studies showed that with respect to the low IGF-1 category, higher IGF-1 was not associated with increased risk of all-cause mortality (HR = 0.84, 95% CI = 0.68-1.05). Dose-response analysis revealed a U-shaped relation between IGF-1 and mortality HR. Pooled results comparing low vs. middle IGF-1 showed a significant increase of all-cause mortality (HR = 1.33, 95% CI = 1.14-1.57), as well as comparing high vs. middle IGF-1 categories (HR = 1.23, 95% CI = 1.06-1.44). Finally, we provide data on the association between IGF-1 levels and the intake of proteins, carbohydrates, certain vitamins/minerals, and specific foods. Both high and low levels of IGF-1 increase mortality risk, with a specific 120-160 ng/ml range being associated with the lowest mortality. These findings can explain the apparent controversy related to the association between IGF-1 levels and mortality.","journal":"Aging Cell","year":2022,"id":238607,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9195,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":863002,"name":"Alberto Montesanto","orcid":"0000-0002-9563-2216","position":1,"is_corresponding":false},{"id":86230,"name":"Edward L. Giovannucci","orcid":"0000-0002-6123-0219","position":2,"is_corresponding":false},{"id":863003,"name":"Hamid Zand","orcid":"0000-0001-7278-9125","position":3,"is_corresponding":false},{"id":863004,"name":"Meisam Barati","orcid":"0009-0003-7651-0373","position":4,"is_corresponding":false},{"id":291366,"name":"John J. Kopchick","orcid":"0000-0003-4561-2177","position":5,"is_corresponding":false},{"id":863005,"name":"Mario G. Mirisola","orcid":"0000-0003-2555-2226","position":6,"is_corresponding":false},{"id":863006,"name":"Vincenzo Lagani","orcid":"0000-0002-6552-6076","position":7,"is_corresponding":false},{"id":863007,"name":"Hiba Bawadi","orcid":"0000-0003-1499-5646","position":8,"is_corresponding":false},{"id":863008,"name":"Raffaele Vardavas","orcid":"0000-0002-8656-7301","position":9,"is_corresponding":false},{"id":863009,"name":"Alessandro Laviano","orcid":"0000-0002-9809-3553","position":10,"is_corresponding":false},{"id":38571,"name":"Kaare Christensen","orcid":"0000-0002-5429-5292","position":11,"is_corresponding":false},{"id":863010,"name":"Giuseppe Passarino","orcid":"0000-0003-4701-9748","position":12,"is_corresponding":false},{"id":231526,"name":"Valter D. Longo","orcid":"0000-0002-0946-7534","position":13,"is_corresponding":false},{"id":863001,"name":"Jamal Rahmani","orcid":"0000-0002-8002-7021","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T00:22:31.741535Z","pmid":"35048526","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}