{"doi":"10.1111/1753-0407.13445","title":"A network meta‐analysis of association between cardiometabolic risk factors and <scp>COVID</scp>‐19 outcome severity","abstract":"BACKGROUND: Cardiometabolic comorbidities have been associated with a higher risk of COVID-19 severity and mortality, but more investigations are needed to determine which comorbidity is more detrimental. METHODS: Embase, Emcare, and MEDLINE were searched systematically for prospective and retrospective studies assessing the associations of cardiometabolic risk factors and COVID-19 outcomes of hospitalization, severity, and mortality among COVID-19-diagnosed patients. Literature search was performed from first publication to May 19, 2021. Study quality was assessed by the Newcastle-Ottawa Scale. RESULTS: From the literature search, 301 studies suggested that all included cardiometabolic risk factors were associated with a higher risk of COVID-19 hospitalization, severity, and mortality, except that overweight was associated with a decreased risk of mortality (relative risk [RR] 0.88; 95% CI, 0.80-0.98). Patients with diabetes (RR 1.46; 95% CI, 1.45-1.47) were most likely to be hospitalized; patients with heart failure had the highest risk for severe COVID-19 outcomes (RR 1.89; 95% CI, 1.71-2.09); while patients with stroke were most susceptible to overall mortality (RR 1.99; 95% CI, 1.90-2.08). In the network meta-analysis, cerebrovascular disease had the highest impact (RR 1.69; 95% CI, 1.65-1.73) on COVID-19 outcomes compared to other cardiometabolic risk factors. For different combinations of risk factors, cardiovascular disease and diabetes combined (RR 6.98; 95% CI, 5.28-9.22) was more detrimental than others. CONCLUSIONS: Considering the high prevalence of cardiometabolic comorbidities and risk of all severe outcomes, patients with cardiometabolic comorbidities should be prioritized in vaccination and treatment development of COVID-19.","journal":"Journal of Diabetes","year":2023,"id":362754,"datarank":0.5106744550343945,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.18109076843396146,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.18109076843396146,"corpus_percentile":62.249555194554034,"corpus_rank":4881,"citation_count":8,"citer_count":7,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5396,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":809279,"name":"Bo Yang","orcid":"0000-0002-9809-4599","position":1,"is_corresponding":false},{"id":1116280,"name":"Yufei Li","orcid":"0000-0001-5940-4606","position":2,"is_corresponding":false},{"id":1116281,"name":"Rachel Huynh","orcid":"0000-0002-1235-4557","position":3,"is_corresponding":false},{"id":1116759,"name":"Samuel Shim","orcid":null,"position":4,"is_corresponding":false},{"id":789652,"name":"Kenneth Lo","orcid":"0000-0003-4624-2737","position":5,"is_corresponding":false},{"id":383865,"name":"Jie Li","orcid":"0000-0002-7529-6040","position":6,"is_corresponding":false},{"id":523939,"name":"Andrew R. Zullo","orcid":"0000-0003-1673-4570","position":7,"is_corresponding":false},{"id":440205,"name":"Wen‐Chih Wu","orcid":"0000-0002-2834-2024","position":8,"is_corresponding":false},{"id":281196,"name":"Simin Liu","orcid":"0000-0003-2098-3844","position":9,"is_corresponding":false},{"id":1116758,"name":"Alina Li","orcid":null,"position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T01:14:23.749325Z","pmid":"37649300","pmcid":"PMC10667650","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}