{"doi":"10.1111/1471-0528.16441","title":"Risk of pre‐eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case–control study","abstract":"OBJECTIVE: To assess whether women with a genetic predisposition to medical conditions known to increase pre-eclampsia risk have an increased risk of pre-eclampsia in pregnancy. DESIGN: Case-control study. SETTING AND POPULATION: Pre-eclampsia cases (n = 498) and controls (n = 1864) in women of European ancestry from five US sites genotyped on a cardiovascular gene-centric array. METHODS: Significant single-nucleotide polymorphisms (SNPs) from 21 traits in seven disease categories (cardiovascular, inflammatory/autoimmune, insulin resistance, liver, obesity, renal and thrombophilia) with published genome-wide association studies (GWAS) were used to create a genetic instrument for each trait. Multivariable logistic regression was used to test the association of each continuous scaled genetic instrument with pre-eclampsia. Odds of pre-eclampsia were compared across quartiles of the genetic instrument and evaluated for significance. MAIN OUTCOME MEASURES: Genetic predisposition to medical conditions and relationship with pre-eclampsia. RESULTS: An increasing burden of risk alleles for elevated diastolic blood pressure (DBP) and increased body mass index (BMI) were associated with an increased risk of pre-eclampsia (DBP, overall OR 1.11, 95% CI 1.01-1.21, P = 0.025; BMI, OR 1.10, 95% CI 1.00-1.20, P = 0.042), whereas alleles associated with elevated alkaline phosphatase (ALP) were protective (OR 0.89, 95% CI 0.82-0.97, P = 0.008), driven primarily by pleiotropic effects of variants in the FADS gene region. The effect of DBP genetic loci was even greater in early-onset pre-eclampsia cases (at <34 weeks of gestation, OR 1.30, 95% CI 1.08-1.56, P = 0.005). For other traits, there was no evidence of an association. CONCLUSIONS: These results suggest that the underlying genetic architecture of pre-eclampsia may be shared with other disorders, specifically hypertension and obesity. TWEETABLE ABSTRACT: A genetic predisposition to increased diastolic blood pressure and obesity increases the risk of pre-eclampsia.","journal":"BJOG An International Journal of Obstetrics & Gynaecology","year":2020,"id":96010,"datarank":0.5416376868966337,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"self_citation_contribution":0.5416376868966337,"citation_network_contribution":0.0,"self_endowment_contribution":0.5416376868966337,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8244,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":477891,"name":"VP Kovacheva","orcid":null,"position":1,"is_corresponding":false},{"id":252195,"name":"Hooman Mirzakhani","orcid":"0000-0002-2290-4436","position":2,"is_corresponding":false},{"id":477892,"name":"A. C. Bjonnes","orcid":null,"position":3,"is_corresponding":false},{"id":83409,"name":"Berta Almoguera","orcid":"0000-0002-5599-2954","position":4,"is_corresponding":false},{"id":298572,"name":"Melissa L. Wilson","orcid":"0000-0001-7785-4221","position":5,"is_corresponding":false},{"id":477893,"name":"SA Ingles","orcid":null,"position":6,"is_corresponding":false},{"id":346968,"name":"Charles J. Lockwood","orcid":"0000-0002-7765-4999","position":7,"is_corresponding":false},{"id":37445,"name":"Håkon Håkonarson","orcid":"0000-0003-2814-7461","position":8,"is_corresponding":false},{"id":477894,"name":"TF McElrath","orcid":null,"position":9,"is_corresponding":false},{"id":477895,"name":"JC Murray","orcid":null,"position":10,"is_corresponding":false},{"id":477896,"name":"ER Norwitz","orcid":null,"position":11,"is_corresponding":false},{"id":293224,"name":"S. Ananth Karumanchi","orcid":"0000-0002-2281-6831","position":12,"is_corresponding":false},{"id":187156,"name":"B.T. Bateman","orcid":null,"position":13,"is_corresponding":false},{"id":477897,"name":"BJ Keating","orcid":null,"position":14,"is_corresponding":false},{"id":249993,"name":"Richa Saxena","orcid":"0000-0003-2233-1065","position":15,"is_corresponding":false},{"id":243047,"name":"Kathryn J. Gray","orcid":"0000-0002-3541-3724","position":0,"is_corresponding":true}],"reference_count":107,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T22:34:34.781847Z","pmid":"32741103","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}