{"doi":"10.1111/1469-7610.00644","title":"The Familial Aggregation of the Lesser Variant in Biological and Nonbiological Relatives of PDD Probands: a Family History Study","abstract":"<jats:p>\n                    <jats:italic>Objective</jats:italic>\n                    : To determine the risk of the lesser variant (or PDD‐like traits) in the biological and nonbiological second‐ and third‐degree relatives of PDD probands using a screening questionnaire and to investigate the extent to which the risk of the lesser variant differs according to various characteristics of the proband.\n                    <jats:italic>Method</jats:italic>\n                    : The sample consists of a series of 34 nuclear families with 2 affected PDD children (multiplex, MPX), 44 families with a single PDD child (simplex, SPX), and 14 families who adopted a PDD child. Data on characteristics of the lesser variant in 1362 biological and 337 nonbiological second‐ and third‐degree relatives were collected from parents by telephone interview and from several maternal and paternal relatives by questionnaire.\n                    <jats:italic>Results</jats:italic>\n                    : All components of the lesser variant were more common in biological relatives (BR) than nonbiological relatives (NBR), confirming the familial aggregation of the traits. Proband characteristics associated with an increased risk of the lesser variant in relatives were a higher level of functioning and coming from a MPX family.\n                    <jats:italic>Conclusions</jats:italic>\n                    : These findings on the familial aggregation of the lesser variant suggest that the genes for PDD also confer susceptibility to the lesser variant and that PDD may be a genetically heterogeneous disorder.\n                  </jats:p>","journal":"Journal of Child Psychology and Psychiatry","year":2000,"id":601432,"datarank":0.7485648880168105,"base_score":4.990432586778736,"endowment":4.990432586778736,"self_citation_contribution":0.7485648880168105,"citation_network_contribution":0.0,"self_endowment_contribution":0.7485648880168105,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":146,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1542150,"name":"Joanna E. MacLean","orcid":null,"position":1,"is_corresponding":false},{"id":1542151,"name":"Marshall B. Jones","orcid":null,"position":2,"is_corresponding":false},{"id":40095,"name":"Susan E. Bryson","orcid":null,"position":3,"is_corresponding":false},{"id":40210,"name":"Lonnie Zwaigenbaum","orcid":null,"position":4,"is_corresponding":false},{"id":1542152,"name":"Giampiero Bartolucci","orcid":null,"position":5,"is_corresponding":false},{"id":40242,"name":"William J. Mahoney","orcid":null,"position":6,"is_corresponding":false},{"id":1542153,"name":"Larry Tuff","orcid":null,"position":7,"is_corresponding":false},{"id":40221,"name":"Peter Szatmari","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Familial Aggregation of the Lesser Variant in Biological and Nonbiological Relatives of PDD Probands: a Family History Study","abstract":"<jats:p>\n                    <jats:italic>Objective</jats:italic>\n                    : To determine the risk of the lesser variant (or PDD‐like traits) in the biological and nonbiological second‐ and third‐degree relatives of PDD probands using a screening questionnaire and to investigate the extent to which the risk of the lesser variant differs according to various characteristics of the proband.\n                    <jats:italic>Method</jats:italic>\n                    : The sample consists of a series of 34 nuclear families with 2 affected PDD children (multiplex, MPX), 44 families with a single PDD child (simplex, SPX), and 14 families who adopted a PDD child. Data on characteristics of the lesser variant in 1362 biological and 337 nonbiological second‐ and third‐degree relatives were collected from parents by telephone interview and from several maternal and paternal relatives by questionnaire.\n                    <jats:italic>Results</jats:italic>\n                    : All components of the lesser variant were more common in biological relatives (BR) than nonbiological relatives (NBR), confirming the familial aggregation of the traits. Proband characteristics associated with an increased risk of the lesser variant in relatives were a higher level of functioning and coming from a MPX family.\n                    <jats:italic>Conclusions</jats:italic>\n                    : These findings on the familial aggregation of the lesser variant suggest that the genes for PDD also confer susceptibility to the lesser variant and that PDD may be a genetically heterogeneous disorder.\n                  </jats:p>","is_dataset_classified":null,"base_score":4.990432586778736,"endowment":4.990432586778736,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10946750","pmcid":null,"openalex_id":"https://openalex.org/W1964953535","authors":[],"funders":[],"total_grants":0,"fwci":2.2584,"citation_percentile":0.87083624,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":11},{"year":2014,"count":6},{"year":2015,"count":7},{"year":2016,"count":7},{"year":2017,"count":5},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":3},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2025,"count":2}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2F1469-7610.00644","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/1469-7610.00644","host_type":"publisher"},{"url":"https://acamh.onlinelibrary.wiley.com/doi/pdf/10.1111/1469-7610.00644","host_type":"publisher"},{"url":"https://doi.org/10.1111/1469-7610.00644","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10946750","host_type":"repository"}],"fields_of_study":["Genetic Associations and Epidemiology","Sexual Differentiation and Disorders","Genomics and Rare Diseases"],"mesh_terms":["Adolescent","Adoption","Adult","Aged","Aged, 80 and over","Autistic Disorder","Child","Child Development Disorders, Pervasive","Family","Female","Humans","Infant","Intelligence","Male","Middle Aged","Phenotype","Surveys and Questionnaires","Sampling Studies","Logistic Models","Sex Distribution","Genetic Predisposition to Disease"],"keywords":["Proband","Family aggregation","Psychology","First-degree relatives","Genetics","Nuclear family","Family history","Biology","Medicine","Gene","Mutation","Population","Environmental health"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T16:21:07.963634Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}