{"doi":"10.1109/tnsre.2005.847387","title":"Emergent epileptiform activity in neural networks with weak excitatory synapses","abstract":null,"journal":"IEEE Transactions on Neural Systems and Rehabilitation Engineering","year":2005,"id":598429,"datarank":0.6610078870896381,"base_score":4.406719247264253,"endowment":4.406719247264253,"self_citation_contribution":0.6610078870896381,"citation_network_contribution":0.0,"self_endowment_contribution":0.6610078870896381,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":81,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1464438,"name":"H.C. Lee","orcid":null,"position":1,"is_corresponding":false},{"id":1533413,"name":"M. Hereld","orcid":null,"position":2,"is_corresponding":false},{"id":1533414,"name":"Zheyan Chen","orcid":null,"position":3,"is_corresponding":false},{"id":1533415,"name":"F.P. Elsen","orcid":null,"position":4,"is_corresponding":false},{"id":1533416,"name":"R.L. Stevens","orcid":null,"position":5,"is_corresponding":false},{"id":1533410,"name":"W. van Drongelen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Emergent epileptiform activity in neural networks with weak excitatory synapses","abstract":"Brain electrical activity recorded during an epileptic seizure is frequently associated with rhythmic discharges in cortical networks. Current opinion in clinical neurophysiology is that strongly coupled networks and cellular bursting are prerequisites for the generation of epileptiform activity. Contrary to expectations, we found that weakly coupled cortical networks can create synchronized cellular activity and seizure-like bursting. Evaluation of a range of synaptic parameters in a detailed computational model revealed that seizure-like activity occurs when the excitatory synapses are weakened. Guided by this observation, we confirmed experimentally that, in mouse neocortical slices, a pharmacological reduction of excitatory synaptic transmission elicited sudden onset of repetitive network bursting. Our finding provides powerful evidence that onset of seizures can be associated with a reduction in synaptic transmission. These results open a new avenue to explore network synchrony and may ultimately lead to a rational approach to treatment of network pathology in epilepsy.","is_dataset_classified":null,"base_score":4.406719247264253,"endowment":4.406719247264253,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16003905","pmcid":null,"openalex_id":"https://openalex.org/W2127532780","authors":[],"funders":[],"total_grants":0,"fwci":1.3097,"citation_percentile":0.77253116,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":8},{"year":2014,"count":4},{"year":2015,"count":7},{"year":2016,"count":6},{"year":2017,"count":4},{"year":2018,"count":5},{"year":2019,"count":2},{"year":2020,"count":8},{"year":2021,"count":6},{"year":2022,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":"https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html","oa_locations":[{"url":"http://xplorestaging.ieee.org/ielx5/7333/31004/01439551.pdf?arnumber=1439551","host_type":"publisher"},{"url":"https://doi.org/10.1109/tnsre.2005.847387","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16003905","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.149.695","host_type":""},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.379.9320","host_type":""}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Neural dynamics and brain function","Neuroscience and Neural Engineering","Animals","Biological Clocks","Computer Simulation","Epilepsy","Excitatory Postsynaptic Potentials","Mice","Models, Neurological","Neocortex","Nerve Net","Neurons","Synaptic Transmission"],"mesh_terms":["Animals","Biological Clocks","Computer Simulation","Epilepsy","Models, Neurological","Nerve Net","Synaptic Transmission","Neurons","Neocortex","Excitatory Postsynaptic Potentials","Mice"],"keywords":["Bursting","Neuroscience","Excitatory postsynaptic potential","Epilepsy","Neurotransmission","Neurophysiology","Biological neural network","Biology","Psychology","Inhibitory postsynaptic potential"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T15:42:01.502158Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}