{"doi":"10.1109/tmi.2024.3486084","title":"Time-Resolved Laser Speckle Contrast Imaging (TR-LSCI) of Cerebral Blood Flow","abstract":"To address many of the deficiencies in optical neuroimaging technologies, such as poor tempo-spatial resolution, low penetration depth, contact-based measurement, and time-consuming image reconstruction, a novel, noncontact, portable, time-resolved laser speckle contrast imaging (TR-LSCI) technique has been developed for continuous, fast, and high-resolution 2D mapping of cerebral blood flow (CBF) at different depths of the head. TR-LSCI illuminates the head with picosecond-pulsed, coherent, widefield near-infrared light and synchronizes a fast, high-resolution, gated single-photon avalanche diode camera to selectively collect diffuse photons with longer pathlengths through the head, thus improving the accuracy of CBF measurement in the deep brain. The reconstruction of a CBF map was dramatically expedited by incorporating convolution functions with parallel computations. The performance of TR-LSCI was evaluated using head-simulating phantoms with known properties and in-vivo rodents with varied hemodynamic challenges to the brain. TR-LSCI enabled mapping CBF variations at different depths with a sampling rate of up to 1 Hz and spatial resolutions ranging from tens/hundreds of micrometers on rodent head surfaces to 1-2 millimeters in deep brains. With additional improvements and validation in larger populations against established methods, we anticipate offering a noncontact, fast, high-resolution, portable, and affordable brain imager for fundamental neuroscience research in animals and for translational studies in humans.","journal":"IEEE Transactions on Medical Imaging","year":2024,"id":435842,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9614,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":383315,"name":"Siavash Mazdeyasna","orcid":"0000-0001-5683-9866","position":1,"is_corresponding":false},{"id":1111077,"name":"Dara Singh","orcid":null,"position":2,"is_corresponding":false},{"id":383314,"name":"Chong Huang","orcid":"0000-0002-5260-9112","position":3,"is_corresponding":false},{"id":383316,"name":"Mehrana Mohtasebi","orcid":"0000-0002-4689-990X","position":4,"is_corresponding":false},{"id":710175,"name":"Xuhui Liu","orcid":"0000-0002-2537-7838","position":5,"is_corresponding":false},{"id":1110499,"name":"Samaneh Rabienia Haratbar","orcid":"0009-0005-3051-2888","position":6,"is_corresponding":false},{"id":653236,"name":"Mingjun Zhao","orcid":"0000-0002-8657-4413","position":7,"is_corresponding":false},{"id":345617,"name":"Li Chen","orcid":"0000-0003-0233-4576","position":8,"is_corresponding":false},{"id":748109,"name":"Arin Can Ülkü","orcid":"0000-0002-6719-6189","position":9,"is_corresponding":false},{"id":1192477,"name":"Paul Moş","orcid":"0009-0003-5909-5147","position":10,"is_corresponding":false},{"id":748110,"name":"Claudio Bruschini","orcid":"0000-0002-6636-6596","position":11,"is_corresponding":false},{"id":237775,"name":"Edoardo Charbon","orcid":"0000-0002-0620-3365","position":12,"is_corresponding":false},{"id":383317,"name":"Lei Chen","orcid":"0000-0002-1218-8704","position":13,"is_corresponding":false},{"id":1243440,"name":"Guoqiang Yu","orcid":"0000-0002-2900-6268","position":14,"is_corresponding":false},{"id":1110500,"name":"Faraneh Fathi","orcid":"0000-0001-8061-6304","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T02:00:08.103086Z","pmid":"39446549","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}