{"doi":"10.1109/tmi.2020.2969376","title":"A Robust Regularizer for Multiphase CT","abstract":"Joint image reconstruction for multiphase CT can potentially improve image quality and reduce dose by leveraging the shared information among the phases. Multiphase CT scans are acquired sequentially. Inter-scan patient breathing causes small organ shifts and organ boundary misalignment among different phases. Existing multi-channel regularizers such as the joint total variation (TV) can introduce artifacts at misaligned organ boundaries. We propose a multi-channel regularizer using the infimal convolution (inf-conv) between a joint TV and a separable TV. It is robust against organ misalignment; it can work like a joint TV or a separable TV depending on a parameter setting. The effects of the parameter in the inf-conv regularizer are analyzed in detail. The properties of the inf-conv regularizer are then investigated numerically in a multi-channel image denoising setting. For algorithm implementation, the inf-conv regularizer is nonsmooth; inverse problems with the inf-conv regularizer can be solved using a number of primal-dual algorithms from nonsmooth convex minimization. Our numerical studies using synthesized 2-phase patient data and phantom data demonstrate that the inf-conv regularizer can largely maintain the advantages of the joint TV over the separable TV and reduce image artifacts of the joint TV due to organ misalignment.","journal":"IEEE Transactions on Medical Imaging","year":2020,"id":113901,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":536646,"name":"Frédéric Noo","orcid":"0000-0002-5417-3439","position":1,"is_corresponding":false},{"id":519026,"name":"Jingyan Xu","orcid":"0000-0003-3047-8198","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-18T23:13:25.964732Z","pmid":"31995477","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}