{"doi":"10.1109/tci.2024.3473312","title":"A Quantum Denoising-Based Resolution Enhancement Framework for 250-MHz and 500-MHz Quantitative Acoustic Microscopy","abstract":"Quantitative acoustic microscopy (QAM) forms two-dimensional (2D) quantitative maps of acoustic properties of thin tissue sections at a microscopic scale (<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><tex-math notation=\"LaTeX\">$&lt; 8\\; \\mu$</tex-math></inline-formula>m) using very-high-frequency (i.e., <inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><tex-math notation=\"LaTeX\">$&gt;$</tex-math></inline-formula> 200 MHz) ultrasonic excitation. Our custom-made QAM systems employ a 250-MHz or a 500-MHz single-element transducer to produce 2D maps with theoretical spatial resolutions smaller than 8 <inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><tex-math notation=\"LaTeX\">$\\mu$</tex-math></inline-formula>m and 4 <inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><tex-math notation=\"LaTeX\">$\\mu$</tex-math></inline-formula>m, respectively. Even with the utilization of these state-of-the-art QAM instruments, spatial resolution still proves insufficient for certain clinical studies. However, designing a QAM system yielding finer resolution (i.e., using a higher-frequency transducer) is expensive and requires expert users. This work proposes a scheme to enhance the spatial resolution of the 2D QAM maps by exploiting an off-the-shelf quantum-based adaptive denoiser (DeQuIP), leveraging the principles of quantum many-body theory. Drawing upon the recent advancement in regularization-by-denoising (RED) for image restoration, we impose this external DeQuIP denoiser as a RED-prior coupled with an analytical solution to address the degradation operators in solving the QAM super-resolution problem. The efficiency of our proposed scheme is demonstrated by improving the resolution of experimental 2D acoustic-impedance maps (2DZMs) generated from data acquired using the 250-MHz and 500-MHz QAM systems. Our scheme demonstrates superior performance in recovering finer and subtle details with enhanced spatial resolution when applied to 2DZMs. For example, a spatial resolution improvement of 40% was achieved when applied to 2DZMs at 250-MHz, outperforming two other state-of-the-art methods, which only yielded 23–32% improvement. These observations highlight the efficacy of the proposed RED scheme.","journal":"IEEE Transactions on Computational Imaging","year":2024,"id":481666,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9593,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":492233,"name":"Jonathan Mamou","orcid":"0000-0002-9412-165X","position":1,"is_corresponding":false},{"id":1081757,"name":"Sayantan Dutta","orcid":"0000-0002-8187-4193","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T02:07:10.067421Z","pmid":"40800037","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}