{"doi":"10.1109/tbme.2024.3379898","title":"Multiscale Optical Imaging Fusion for Cervical Precancer Diagnosis: Integrating Widefield Colposcopy and High-Resolution Endomicroscopy","abstract":"OBJECTIVE: Early detection and treatment of cervical precancers can prevent disease progression. However, in low-resource communities with a high incidence of cervical cancer, high equipment costs and a shortage of specialists hinder preventative strategies. This manuscript presents a low-cost multiscale in vivo optical imaging system coupled with a computer-aided diagnostic system that could enable accurate, real-time diagnosis of high-grade cervical precancers. METHODS: The system combines portable colposcopy and high-resolution endomicroscopy (HRME) to acquire spatially registered widefield and microscopy videos. A multiscale imaging fusion network (MSFN) was developed to identify cervical intraepithelial neoplasia grade 2 or more severe (CIN 2+). The MSFN automatically identifies and segments the ectocervix and lesions from colposcopy images, extracts nuclear morphology features from HRME videos, and integrates the colposcopy and HRME information. RESULTS: With a threshold value set to achieve sensitivity equal to clinical impression (0.98 [p = 1.0]), the MSFN achieved a significantly higher specificity than clinical impression (0.75 vs. 0.43, p = 0.000006). CONCLUSION: Our findings show that multiscale optical imaging of the cervix allows the highly sensitive and specific detection of high-grade precancers. SIGNIFICANCE: The multiscale imaging system and MSFN could facilitate the accurate, real-time diagnosis of cervical precancers in low-resource settings.","journal":"IEEE Transactions on Biomedical Engineering","year":2024,"id":436383,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9521,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":517949,"name":"Mila Pontremoli Salcedo","orcid":"0000-0002-6375-0736","position":1,"is_corresponding":false},{"id":294094,"name":"Jackson B. Coole","orcid":"0000-0002-8821-4139","position":2,"is_corresponding":false},{"id":1004923,"name":"Yajur Maker","orcid":"0000-0003-1167-0512","position":3,"is_corresponding":false},{"id":1005250,"name":"Alex Kortum","orcid":null,"position":4,"is_corresponding":false},{"id":370439,"name":"Richard A. Schwarz","orcid":null,"position":5,"is_corresponding":false},{"id":424983,"name":"Jennifer Carns","orcid":"0000-0002-4026-0558","position":6,"is_corresponding":false},{"id":451834,"name":"Imran S. Vohra","orcid":"0000-0002-4750-1254","position":7,"is_corresponding":false},{"id":1244449,"name":"Júlio César Possati‐Resende","orcid":"0000-0002-7869-3885","position":8,"is_corresponding":false},{"id":1244810,"name":"Márcio Antoniazzi","orcid":null,"position":9,"is_corresponding":false},{"id":1244450,"name":"Bruno de Oliveira Fonseca","orcid":"0000-0002-2052-9249","position":10,"is_corresponding":false},{"id":1244451,"name":"Karen Cristina Borba Souza","orcid":"0009-0006-9576-9470","position":11,"is_corresponding":false},{"id":1244452,"name":"Iara Viana Vidigal Santana","orcid":"0000-0002-6507-5287","position":12,"is_corresponding":false},{"id":1244453,"name":"Flávia Fazzio Barbin","orcid":"0000-0002-8140-7691","position":13,"is_corresponding":false},{"id":399650,"name":"Régis Kreitchmann","orcid":"0000-0002-1146-0497","position":14,"is_corresponding":false},{"id":367334,"name":"Nirmala Ramanujam","orcid":"0000-0001-7319-8415","position":15,"is_corresponding":false},{"id":268553,"name":"Kathleen M. Schmeler","orcid":"0000-0002-9670-4189","position":16,"is_corresponding":false},{"id":294099,"name":"Rebecca Richards‐Kortum","orcid":"0000-0003-2347-9467","position":17,"is_corresponding":false},{"id":451833,"name":"David Brenes","orcid":"0000-0003-1969-5386","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-19T02:00:12.706156Z","pmid":"38507389","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}