{"doi":"10.1109/tbcas.2024.3407794","title":"Low-Power Fully Integrated 256-Channel Nanowire Electrode-on-Chip Neural Interface for Intracellular Electrophysiology","abstract":"Intracellular electrophysiology, a vital and versatile technique in cellular neuroscience, is typically conducted using the patch-clamp method. Despite its effectiveness, this method poses challenges due to its complexity and low throughput. The pursuit of multi-channel parallel neural intracellular recording has been a long-standing goal, yet achieving reliable and consistent scaling has been elusive because of several technological barriers. In this work, we introduce a micropower integrated circuit, optimized for scalable, high-throughput in vitro intrinsically intracellular electrophysiology. This system is capable of simultaneous recording and stimulation, implementing all essential functions such as signal amplification, acquisition, and control, with a direct interface to electrodes integrated on the chip. The electrophysiology system-on-chip (eSoC), fabricated in 180nm CMOS, measures 2.236 mm 2.236 mm. It contains four 8 8 arrays of nanowire electrodes, each with a 50 m pitch, placed over the top-metal layer on the chip surface, totaling 256 channels. Each channel has a power consumption of 0.47 W, suitable for current stimulation and voltage recording, and covers 80 dB adjustable range at a sampling rate of 25 kHz. Experimental recordings with the eSoC from cultured neurons in vitro validate its functionality in accurately resolving chemically induced multi-unit intracellular electrical activity.","journal":"IEEE Transactions on Biomedical Circuits and Systems","year":2024,"id":461139,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1289675,"name":"Ren Liu","orcid":"0009-0005-0936-1552","position":1,"is_corresponding":false},{"id":663784,"name":"Youngbin Tchoe","orcid":"0000-0001-7807-5318","position":2,"is_corresponding":false},{"id":810357,"name":"Alessio Paolo Buccino","orcid":"0000-0003-3661-527X","position":3,"is_corresponding":false},{"id":869003,"name":"Akshay Paul","orcid":"0000-0003-3434-5456","position":4,"is_corresponding":false},{"id":663785,"name":"Deborah Prè","orcid":"0000-0002-0163-9514","position":5,"is_corresponding":false},{"id":263542,"name":"Agnieszka D’Antonio‐Chronowska","orcid":"0000-0003-1653-4106","position":6,"is_corresponding":false},{"id":1290097,"name":"Frazer A. Kelly","orcid":null,"position":7,"is_corresponding":false},{"id":227993,"name":"Anne G. Bang","orcid":"0000-0002-1174-9258","position":8,"is_corresponding":false},{"id":1289676,"name":"Chul Kim","orcid":"0000-0002-3882-6022","position":9,"is_corresponding":false},{"id":252411,"name":"Shadi A. Dayeh","orcid":"0000-0002-1756-1774","position":10,"is_corresponding":false},{"id":752334,"name":"Gert Cauwenberghs","orcid":"0000-0002-3166-5529","position":11,"is_corresponding":false},{"id":743126,"name":"Jun Wang","orcid":"0000-0001-8955-3530","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:04:12.271488Z","pmid":"38985549","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}