{"doi":"10.1109/ojuffc.2025.3613275","title":"Double Profile Intersection (DoPIo) Ultrasound With Acoustic Radiation Force Tilting Interrogates Young’s Modulus in Transversely Isotropic Media: An In Silico Study","abstract":"This study evaluates the potential for interrogating the Young's elastic moduli in anisotropic media, including tissue, using Double Profile Intersection (DoPIo) ultrasound. DoPIo is an on-axis acoustic radiation force (ARF)-based elasticity imaging method that quantifies shear elasticity without relying on shear wave propagation. It is hypothesized that by applying a range of ARF excitations that are not perpendicular to the axis of symmetry (AoS) of transversely isotropic (TI) materials and monitoring the resultant variation in DoPIo-measured elasticity versus excitation angle, the Young's elastic modulus may be interrogated in addition to the shear elastic modulus. The hypothesis was tested <italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">in silico</i>, and results suggested that while DoPIo outcomes measured at normal (90°) ARF-AoS incidence were related to the shear elastic modulus alone, variation in DoPIo-derived elasticity over ARF-AoS incidence angle (defined as <italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">ΔElasticity</i>) exhibited a strong linear correlation with the longitudinal Young’s modulus (<italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">E<sub>L</sub></i>). The results suggest that <italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">E<sub>L</sub></i> evaluated by the rate of change of <italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">ΔElasticity</i> with ARF-AoS incidence angle may serve as a novel biomarker for characterizing elastically anisotropic tissues such as kidney, skeletal muscle, and breast.","journal":"IEEE Open Journal of Ultrasonics Ferroelectrics and Frequency Control","year":2025,"id":578560,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9629,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":563422,"name":"Keita A. Yokoyama","orcid":"0000-0003-4386-8056","position":1,"is_corresponding":false},{"id":426946,"name":"Caterina M. Gallippi","orcid":"0000-0003-0514-177X","position":2,"is_corresponding":false},{"id":1487280,"name":"Sabiq Muhtadi","orcid":"0000-0003-0497-0808","position":0,"is_corresponding":true}],"reference_count":12,"raw_metadata":null,"created_at":"2026-07-19T02:58:20.638044Z","pmid":"41114379","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}