{"doi":"10.1109/ojemb.2023.3236267","title":"Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure","abstract":"<italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">Goal:</i> Cerebrovascular impedance is modulated by a vasoactive autoregulative mechanism in response to changes in cerebral perfusion pressure. Characterization of impedance and the limits of autoregulation are important biomarkers of cerebral health. We developed a method to quantify impedance based on the spectral content of cerebral blood flow and volume at the cardiac frequency, measured with diffuse optical methods. <italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">Methods:</i> In three non-human primates, we modulated cerebral perfusion pressure beyond the limits of autoregulation. Cerebral blood flow and volume were measured with diffuse correlation spectroscopy and near-infrared spectroscopy, respectively. <italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">Results:</i> We show that impedance can be used to identify the lower and upper limits of autoregulation. <italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">Conclusions:</i> This impedance method may be an alternative method to measure autoregulation and a way of assessing cerebral health non-invasively at the clinical bedside.","journal":"IEEE Open Journal of Engineering in Medicine and Biology","year":2023,"id":387368,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9583,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":319815,"name":"Deepshikha Acharya","orcid":"0000-0002-5933-0528","position":1,"is_corresponding":false},{"id":1156524,"name":"William B. Scammon","orcid":null,"position":2,"is_corresponding":false},{"id":319814,"name":"Samantha Schmitt","orcid":"0000-0001-9853-7807","position":3,"is_corresponding":false},{"id":887054,"name":"Emily Crane","orcid":"0000-0002-6207-3163","position":4,"is_corresponding":false},{"id":258914,"name":"Matthew A. Smith","orcid":"0000-0003-1192-9942","position":5,"is_corresponding":false},{"id":319816,"name":"Jana M. Kainerstorfer","orcid":"0000-0002-9481-8377","position":6,"is_corresponding":false},{"id":319813,"name":"Jason Yang","orcid":"0000-0002-9970-3333","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:18:04.706547Z","pmid":"37234191","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}