{"doi":"10.1109/ojemb.2021.3116490","title":"RADx Variant Task Force Program for Assessing the Impact of Variants on SARS-CoV-2 Molecular and Antigen Tests","abstract":"<italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">Goal:</i> Monitoring the genetic diversity and emerging mutations of SARS-CoV-2 is crucial for understanding the evolution of the virus and assuring the performance of diagnostic tests, vaccines, and therapies against COVID-19. SARS-CoV-2 is still adapting to humans and, as illustrated by B.1.1.7 (Alpha) and B.1.617.2 (Delta), lineage dynamics are fluid, and strain prevalence may change radically in a matter of months. The National Institutes of Health's Rapid Acceleration of Diagnostics (RADx <sup xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">SM</sup> ) initiative created a Variant Task Force to assess the impact of emerging SARS-CoV-2 variants on <italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">in vitro</i> diagnostic testing. Working in tandem with clinical laboratories, the FDA, and the CDC, the Variant Task Force uses both <italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">in silico</i> modeling and <italic xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">in vitro</i> testing to determine the effect of SARS-CoV-2 mutations on diagnostic molecular and antigen tests. Here, we offer an overview of the approach and activities of the RADx Variant Task Force to ensure test performance against emerging SARS-CoV-2 lineages.","journal":"IEEE Open Journal of Engineering in Medicine and Biology","year":2021,"id":191327,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8276,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":756894,"name":"John Blackwood","orcid":null,"position":1,"is_corresponding":false},{"id":756895,"name":"T Pribýl","orcid":null,"position":2,"is_corresponding":false},{"id":314483,"name":"Leda Bassit","orcid":"0000-0001-9894-5587","position":3,"is_corresponding":false},{"id":402297,"name":"Anuradha Rao","orcid":"0000-0001-6600-0677","position":4,"is_corresponding":false},{"id":756449,"name":"Morgan Greenleaf","orcid":"0000-0003-1569-5696","position":5,"is_corresponding":false},{"id":226170,"name":"Filipp Frank","orcid":"0000-0001-8680-2757","position":6,"is_corresponding":false},{"id":337554,"name":"Wilbur A. Lam","orcid":"0000-0002-0325-7990","position":7,"is_corresponding":false},{"id":74596,"name":"Eric A. Ortlund","orcid":"0000-0001-8855-3029","position":8,"is_corresponding":false},{"id":228075,"name":"Raymond F. Schinazi","orcid":"0000-0002-6688-3614","position":9,"is_corresponding":false},{"id":108342,"name":"Alexander L. Greninger","orcid":"0000-0002-7443-0527","position":10,"is_corresponding":false},{"id":756450,"name":"Mia Cirrincione","orcid":"0000-0001-6587-5674","position":11,"is_corresponding":false},{"id":756896,"name":"Dale Gort","orcid":null,"position":12,"is_corresponding":false},{"id":756897,"name":"Emily B. Kennedy","orcid":null,"position":13,"is_corresponding":false},{"id":756898,"name":"Adam Samuta","orcid":null,"position":14,"is_corresponding":false},{"id":756899,"name":"Megan K. Shaw","orcid":null,"position":15,"is_corresponding":false},{"id":740230,"name":"Brian Walsh","orcid":"0000-0001-5151-0674","position":16,"is_corresponding":false},{"id":756451,"name":"Eric Lai","orcid":"0000-0002-1997-5241","position":17,"is_corresponding":false},{"id":756448,"name":"Richard S. Creager","orcid":"0000-0001-5488-4444","position":0,"is_corresponding":true}],"reference_count":12,"raw_metadata":null,"created_at":"2026-07-18T23:49:31.121780Z","pmid":"35257097","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}