{"doi":"10.1109/jstqe.2025.3575719","title":"Pathlength-Selective, Interferometric Diffuse Correlation Spectroscopy","abstract":"In this work, we present an enhanced diffuse correlation spectroscopy (DCS) method called pathlength-selective, interferometric DCS (PaLS-iDCS), which uses pathlength-specific coherent gain to improve both the sensitivity to deep tissue hemodynamics and measurement SNR. Through interferometric detection, PaLS-iDCS can provide time-of-flight (ToF) specific blood flow information without the use of expensive time-tagging electronics and low-jitter detectors. The technique is compared to time-domain DCS (TD-DCS), another enhanced DCS method able to resolve photon ToF in tissue, through Monte Carlo simulation, phantom experiments, and human subject measurements. PaLS-iDCS consistently demonstrates improvements in SNR (>2x) for similar measurement conditions (same photon ToF), and the SNR improvements allow for measurements at extended photon ToFs, which have increased sensitivity to deep tissue hemodynamics (~50% increase). Further, like TD-DCS, PaLS-iDCS allows direct estimation of tissue optical properties from the sampled ToF distribution. This method offers a relatively straightforward way to allow DCS systems to make robust measurements of blood flow with greatly enhanced sensitivity to deep tissue hemodynamics without the need for time-resolved detection, enabling further applications of this non-invasive technology.","journal":"IEEE Journal of Selected Topics in Quantum Electronics","year":2025,"id":530751,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":878498,"name":"Marco Renna","orcid":"0000-0002-8143-5131","position":1,"is_corresponding":false},{"id":1254881,"name":"Nikola Otic","orcid":"0009-0004-9032-1250","position":2,"is_corresponding":false},{"id":1411119,"name":"Olivia S. Kierul","orcid":null,"position":3,"is_corresponding":false},{"id":1411120,"name":"Ailis Muldoon","orcid":null,"position":4,"is_corresponding":false},{"id":291374,"name":"Maria Angela Franceschini","orcid":"0000-0001-6758-423X","position":5,"is_corresponding":false},{"id":291368,"name":"Stefan A. Carp","orcid":"0000-0003-4617-3233","position":6,"is_corresponding":false},{"id":291371,"name":"Mitchell B. Robinson","orcid":"0000-0001-5810-0459","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-19T02:51:10.077559Z","pmid":"40766943","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}