{"doi":"10.1109/jstqe.2022.3221338","title":"A Real-Time Fluorescence Feedback System for Infrared Laser Sealing of Blood Vessels","abstract":"This study explores UV light induced fluorescence from blood vessels for indicating successful infrared laser sealing of vascular tissues. A light emitting diode (LED) with center wavelength of 340 nm and 0.1 mW power was used with a Y-shaped fiber bundle of seven 200-μm-core fibers. The central excitation fiber was connected to the LED, while the detection ring of six fibers was connected to a spectrometer. The fiber bundle was aligned with porcine renal arteries compressed between optical windows. Fluorescence was acquired before and after vessel sealing, with a 1470 nm laser for 5 s at 30 W (sealing, n = 10) or 5 W (control, n = 10). Signal increase in the 470-520 nm spectrum was correlated with vessel burst pressures (BP). Integrated fluorescence increased 71 ± 25% at 30 W vs. 19 ± 14% at 5 W (p < 0.05), corresponding to a successful BP of 639 ± 189 mmHg vs. failed seal BP of 39 ± 41 mmHg (p < 0.05). Real-time measurements showed a gradual increase in fluorescence with the signal reaching a plateau at 3-4 s, indicating that shorter seal times are possible. The increase in fluorescence signal during laser vessel sealing may provide a non-destructive, real-time, optical method for indicating hemostatic seals.","journal":"IEEE Journal of Selected Topics in Quantum Electronics","year":2022,"id":279008,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9617,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":422159,"name":"Nathaniel M. Fried","orcid":"0000-0003-1275-7716","position":1,"is_corresponding":false},{"id":952620,"name":"Woheeb M. Saeed","orcid":null,"position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T00:28:51.322666Z","pmid":"36466144","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}