{"doi":"10.1109/ius62464.2025.11201469","title":"A Piezo-Cmut Hybrid Hemispherical Transmit Array for Passive Acoustic Mapping of Microbubble Activity","abstract":"Transcranial focused ultrasound (tFUS) combined with microbubbles (MBs) is a promising technique for transiently opening the blood–brain barrier (BBB) to enhance drug delivery. Large-Scale systems for BBB opening typically rely on piezoelectric transducers for both ultrasound transmission and microbubble emission detection. Capacitive micromachined ultrasonic transducers (CMUTs), with their wide bandwidth, have been explored as passive cavitation detectors; however, their role as receivers in large-scale tFUS systems remains underexplored. In this work, we present the design and characterization of a hemispherical transmit array operating at 400 kHz, integrated with a CMUT receiver for detecting MB-generated nonlinear harmonics. A tube phantom with circulating water and MBs was used to emulate vascular conditions. Spectral analysis of CMUT signals revealed clear detection of the fourth harmonic at 1.6 MHz with a signal-to-noise ratio of approximately 10 dB, confirming the feasibility of hybrid piezo–CMUT systems for harmonic monitoring during BBB opening.","journal":null,"year":2025,"id":578597,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":634969,"name":"Hohyun Lee","orcid":"0000-0002-7939-6751","position":1,"is_corresponding":false},{"id":1372745,"name":"Yann Ferry","orcid":null,"position":2,"is_corresponding":false},{"id":1488895,"name":"Bryant Ingram","orcid":null,"position":3,"is_corresponding":false},{"id":1359507,"name":"Benjamin Skowronski","orcid":null,"position":4,"is_corresponding":false},{"id":748371,"name":"Pradosh Pritam Dash","orcid":"0000-0002-9290-6859","position":5,"is_corresponding":false},{"id":1294830,"name":"Reza Pakdaman Zangabad","orcid":"0000-0002-5927-524X","position":6,"is_corresponding":false},{"id":625982,"name":"Costas Arvanitis","orcid":"0000-0002-7737-1446","position":7,"is_corresponding":false},{"id":418355,"name":"F. Levent Degertekin","orcid":"0000-0001-9198-8525","position":8,"is_corresponding":false},{"id":634968,"name":"M. Sait Kilinc","orcid":"0000-0002-3907-9890","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T02:58:24.957414Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}