{"doi":"10.1109/ius46767.2020.9251308","title":"Controlled Release of Basic Fibroblast Growth Factor (bFGF) using Therapeutic Ultrasound Enhances Angiogenesis and Reperfusion in Ischemic Muscle","abstract":"Current treatment options for critical limb ischemia (CLI), an advanced type of peripheral artery disease (PAD), are grossly insufficient. Clinical trials have evaluated exogenous, pro-angiogenic growth factors to stimulate angiogenesis in PAD/CLI. However, conventional administration routes are ineffective for growth factors, which have contributed to translational challenges. We have developed a composite hydrogel scaffold, termed an acoustically-responsive scaffold (ARS), where growth factor delivery is controlled via acoustic droplet vaporization (ADV). The ARS consists of a phase-shift emulsion contained within a fibrin matrix. We demonstrate in a mouse model of CLI that ADV can be used to enhance angiogenesis and perfusion via the release of basic fibroblast growth factor (bFGF) from implanted ARSs.","journal":null,"year":2020,"id":131618,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":586386,"name":"Carole Quesada","orcid":null,"position":1,"is_corresponding":false},{"id":585738,"name":"Leidan Huang","orcid":"0000-0001-6161-8750","position":2,"is_corresponding":false},{"id":465311,"name":"Mitra Aliabouzar","orcid":"0000-0002-7441-3479","position":3,"is_corresponding":false},{"id":496246,"name":"Aniket Jivani","orcid":"0000-0003-3379-7514","position":4,"is_corresponding":false},{"id":366611,"name":"Oliver D. Kripfgans","orcid":"0000-0003-2905-1496","position":5,"is_corresponding":false},{"id":366619,"name":"J. Brian Fowlkes","orcid":"0000-0002-4536-3919","position":6,"is_corresponding":false},{"id":310274,"name":"Renny T. Franceschi","orcid":"0000-0003-1405-2541","position":7,"is_corresponding":false},{"id":585739,"name":"Jianhua Liu","orcid":"0000-0001-8628-0127","position":8,"is_corresponding":false},{"id":367191,"name":"Andrew J. Putnam","orcid":"0000-0002-1262-4377","position":9,"is_corresponding":false},{"id":310273,"name":"Mario L. Fabiilli","orcid":"0000-0002-4752-9812","position":10,"is_corresponding":false},{"id":585737,"name":"Hai Jin","orcid":"0000-0002-2264-1699","position":0,"is_corresponding":true}],"reference_count":5,"raw_metadata":null,"created_at":"2026-07-18T23:16:03.875886Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}