{"doi":"10.1109/embc48229.2022.9871359","title":"Image-Level Uncertainty in Pseudo-Label Selection for Semi-Supervised Segmentation","abstract":"Advancements in deep learning techniques have proved useful in biomedical image segmentation. However, the large amount of unlabeled data inherent in biomedical imagery, particularly in digital pathology, creates a semi-supervised learning paradigm. Specifically, because of the time consuming nature of producing pixel-wise annotations and the high cost of having a pathologist dedicate time to labeling, there is a large amount of unlabeled data that we wish to utilize in training segmentation algorithms. Pseudo-labeling is one method to leverage the unlabeled data to increase overall model performance. We adapt a method used for image classification pseudo-labeling to select images for segmentation pseudo-labeling and apply it to 3 digital pathology datasets. To select images for pseudo-labeling, we create and explore different thresholds for confidence and uncertainty on an image level basis. Furthermore, we study the relationship between image-level uncertainty and confidence with model performance. We find that the certainty metrics do not consistently correlate with performance intuitively, and abnormal correlations serve as an indicator of a model's ability to produce pseudo-labels that are useful in training. Clinical relevance - The proposed approach adapts image-level confidence and uncertainty measures for segmentation pseudo-labeling on digital pathology datasets. Increased model performance enables better disease quantification for histopathology.","journal":"2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","year":2022,"id":304236,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9408,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":772174,"name":"Fatima Zulqarnain","orcid":null,"position":1,"is_corresponding":false},{"id":68454,"name":"Sana Syed","orcid":"0000-0003-0954-0583","position":2,"is_corresponding":false},{"id":315122,"name":"Donald Brown","orcid":"0000-0002-9140-2632","position":3,"is_corresponding":false},{"id":997651,"name":"Payden McBee","orcid":null,"position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T00:32:32.651796Z","pmid":"36086227","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}