{"doi":"10.1109/embc.2014.6944160","title":"Localization of subthalamic nucleus borders using macroelectrode local field potential recordings","abstract":null,"journal":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","year":2014,"id":615655,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1586977,"name":"N. F. Ince","orcid":null,"position":1,"is_corresponding":false},{"id":1586979,"name":"I. Onaran","orcid":null,"position":2,"is_corresponding":false},{"id":1586981,"name":"A. Abosch","orcid":null,"position":3,"is_corresponding":false},{"id":1586976,"name":"I. Telkes","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Localization of subthalamic nucleus borders using macroelectrode local field potential recordings","abstract":"Deep brain stimulation of the subthalamic nucleus (STN) is a highly effective treatment for motor symptoms of Parkinson's disease. However, precise intraoperative localization of STN remains a procedural challenge. In the present study, local field potentials (LFPs) were recorded from DBS macroelectrodes during trajectory to STN, in six patients. The frequency-vs-depth map of LFP activity was extracted and further analyzed within different sub-bands, to investigate whether LFP activity can be used for STN border identification. STN borders identified by LFPs were compared to border predictions by the neurosurgeon, based on microelectrode-derived, single-unit recordings (MER-SUA). The results demonstrate difference between MER-SUA and macroelectrode LFP recording with respect to the dorsal STN border of -1.00 ±0.84 mm and -0.42 ±1.07 mm in the beta and gamma frequency bands, respectively. For these sub-bands, RMS of these distances was found to be 1.26 mm and 1.06 mm, respectively. Analysis of other sub-bands did not allow for distinguishing the caudal border of STN. In conclusion, macroelectrode-derived LFP recordings may provide an alternative approach to MER-SUA, for localizing the target STN borders during DBS surgery.","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25570528","pmcid":null,"openalex_id":"https://openalex.org/W2330101293","authors":[],"funders":[],"total_grants":0,"fwci":7.6026,"citation_percentile":0.96790541,"influential_citations":0,"citation_trend":[{"year":2016,"count":3},{"year":2017,"count":3},{"year":2018,"count":3},{"year":2020,"count":3},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://xplorestaging.ieee.org/ielx7/6923026/6943513/06944160.pdf?arnumber=6944160","host_type":"publisher"},{"url":"https://doi.org/10.1109/embc.2014.6944160","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/25570528","host_type":"repository"}],"fields_of_study":["Neurological disorders and treatments","Parkinson's Disease Mechanisms and Treatments","Neuroscience and Neural Engineering"],"mesh_terms":["Humans","Microelectrodes","Middle Aged","Parkinson Disease","Treatment Outcome","Subthalamic Nucleus","Deep Brain Stimulation"],"keywords":["Local field potential","Subthalamic nucleus","Deep brain stimulation","Neuroscience","Motor symptoms","Psychology","Dorsum","Parkinson's disease","Computer science","Medicine","Anatomy","Disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T20:42:19.823742Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}