{"doi":"10.1108/rpj-10-2018-0264","title":"3D bioprinting of tissue engineering scaffold for cell culture","abstract":"<jats:sec>\n<jats:title content-type=\"abstract-subheading\">Purpose</jats:title>\n<jats:p>The 3 D bioprinting technology is used to prepare the tissue engineering scaffold with precise structures for the cell proliferation and differentiation.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title content-type=\"abstract-subheading\">Design/methodology/approach</jats:title>\n<jats:p>According to the characteristics of the ideal tissue engineering scaffold, the microstructural design of the tissue engineering scaffold is carried out. The bioprinter is used to fabricate the tissue engineering scaffold with different structures and spacing sizes. Finally, the scaffold with good connectivity is achieved and used to cell PC12 culture.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title content-type=\"abstract-subheading\">Findings</jats:title>\n<jats:p>The results show that the pore structure with the line spacing of 1 mm was the best for cell culture, and the survival rate of the inoculated cells PC12 is as high as 90%. The influence of the pore shape on the cell survival is not evidence.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title content-type=\"abstract-subheading\">Originality/value</jats:title>\n<jats:p>This study shows that tissue engineering scaffolds prepared by 3 D bioprinting have graded structure for three-dimensional cell culture, which lays the foundation for the later detection of drug resistance.</jats:p>\n</jats:sec>","journal":"Rapid Prototyping Journal","year":2020,"id":608495,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1201639,"name":"Xinxin Li","orcid":"0009-0005-3188-1503","position":1,"is_corresponding":false},{"id":1562888,"name":"Tianmin Guan","orcid":null,"position":2,"is_corresponding":false},{"id":546964,"name":"Yong Chen","orcid":"0000-0002-9820-1614","position":3,"is_corresponding":false},{"id":1562889,"name":"Chunwei Qi","orcid":null,"position":4,"is_corresponding":false},{"id":576943,"name":"Li Wu","orcid":"0000-0002-5468-2487","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"3D bioprinting of tissue engineering scaffold for cell culture","abstract":"<jats:sec>\n<jats:title content-type=\"abstract-subheading\">Purpose</jats:title>\n<jats:p>The 3 D bioprinting technology is used to prepare the tissue engineering scaffold with precise structures for the cell proliferation and differentiation.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title content-type=\"abstract-subheading\">Design/methodology/approach</jats:title>\n<jats:p>According to the characteristics of the ideal tissue engineering scaffold, the microstructural design of the tissue engineering scaffold is carried out. The bioprinter is used to fabricate the tissue engineering scaffold with different structures and spacing sizes. Finally, the scaffold with good connectivity is achieved and used to cell PC12 culture.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title content-type=\"abstract-subheading\">Findings</jats:title>\n<jats:p>The results show that the pore structure with the line spacing of 1 mm was the best for cell culture, and the survival rate of the inoculated cells PC12 is as high as 90%. The influence of the pore shape on the cell survival is not evidence.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title content-type=\"abstract-subheading\">Originality/value</jats:title>\n<jats:p>This study shows that tissue engineering scaffolds prepared by 3 D bioprinting have graded structure for three-dimensional cell culture, which lays the foundation for the later detection of drug resistance.</jats:p>\n</jats:sec>","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W3003069570","authors":[],"funders":[],"total_grants":0,"fwci":0.4267,"citation_percentile":0.56348135,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.emerald.com/insight/site-policies","oa_locations":[{"url":"https://www.emerald.com/insight/content/doi/10.1108/RPJ-10-2018-0264/full/xml","host_type":"publisher"},{"url":"https://www.emerald.com/insight/content/doi/10.1108/RPJ-10-2018-0264/full/html","host_type":"publisher"},{"url":"https://doi.org/10.1108/rpj-10-2018-0264","host_type":"journal"}],"fields_of_study":["3D Printing in Biomedical Research","Additive Manufacturing and 3D Printing Technologies","Innovative Microfluidic and Catalytic Techniques Innovation"],"mesh_terms":[],"keywords":["Scaffold","Tissue engineering","Materials science","Biomedical engineering","Cell culture","3D cell culture","Engineering","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T17:20:28.269731Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}