{"doi":"10.1105/tpc.17.00272","title":"Evolutionary Footprints Reveal Insights into Plant MicroRNA Biogenesis","abstract":null,"journal":"The Plant Cell","year":2017,"id":657840,"datarank":2.3924714699132963,"base_score":4.3694478524670215,"endowment":4.3694478524670215,"self_citation_contribution":0.6554171778700533,"citation_network_contribution":1.7370542920432432,"self_endowment_contribution":0.6554171778700533,"citer_contribution":1.7370542920432432,"corpus_percentile":null,"corpus_rank":null,"citation_count":78,"citer_count":69,"citers_with_citation_signal":56,"citers_with_endowment":56,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1717267,"name":"Belen Moro","orcid":"0000-0002-2810-3533","position":1,"is_corresponding":false},{"id":1456447,"name":"Arantxa M. L. Rojas","orcid":"0000-0003-4316-4518","position":2,"is_corresponding":false},{"id":110296,"name":"Juan M. Debernardi","orcid":"0000-0002-4591-7061","position":3,"is_corresponding":false},{"id":1717268,"name":"Arnaldo L. Schapire","orcid":null,"position":4,"is_corresponding":false},{"id":208586,"name":"Cedric Notredame","orcid":null,"position":5,"is_corresponding":false},{"id":110301,"name":"Javier F. Palatnik","orcid":"0000-0001-7996-5224","position":6,"is_corresponding":false},{"id":1717266,"name":"Uciel Chorostecki","orcid":"0000-0003-2229-6853","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Evolutionary Footprints Reveal Insights into Plant MicroRNA Biogenesis","abstract":"MicroRNAs (miRNAs) are endogenous small RNAs that recognize target sequences by base complementarity and play a role in the regulation of target gene expression. They are processed from longer precursor molecules that harbor a fold-back structure. Plant miRNA precursors are quite variable in size and shape, and are recognized by the processing machinery in different ways. However, ancient miRNAs and their binding sites in target genes are conserved during evolution. Here, we designed a strategy to systematically analyze MIRNAs from different species generating a graphical representation of the conservation of the primary sequence and secondary structure. We found that plant MIRNAs have evolutionary footprints that go beyond the small RNA sequence itself, yet their location along the precursor depends on the specific MIRNA. We show that these conserved regions correspond to structural determinants recognized during the biogenesis of plant miRNAs. Furthermore, we found that the members of the miR166 family have unusual conservation patterns and demonstrated that the recognition of these precursors in vivo differs from other known miRNAs. Our results describe a link between the evolutionary conservation of plant MIRNAs and the mechanisms underlying the biogenesis of these small RNAs and show that the MIRNA pattern of conservation can be used to infer the mode of miRNA biogenesis.","is_dataset_classified":null,"base_score":4.3694478524670215,"endowment":4.3694478524670215,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28550151","pmcid":null,"openalex_id":"https://openalex.org/W2951218110","authors":[],"funders":[],"total_grants":0,"fwci":14.7974,"citation_percentile":0.98687084,"influential_citations":0,"citation_trend":[{"year":2017,"count":4},{"year":2018,"count":12},{"year":2019,"count":8},{"year":2020,"count":7},{"year":2021,"count":16},{"year":2022,"count":5},{"year":2023,"count":7},{"year":2024,"count":8},{"year":2025,"count":9},{"year":2026,"count":2}],"oa_status":"hybrid","license":"other-oa","oa_locations":[{"url":"http://www.plantcell.org/content/plantcell/29/6/1248.full.pdf","host_type":"journal"},{"url":"http://www.plantcell.org/content/plantcell/29/6/1248.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1105/tpc.17.00272","host_type":"publisher"},{"url":"https://doi.org/10.1105/tpc.17.00272","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28550151","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5502457","host_type":"repository"}],"fields_of_study":["Plant Molecular Biology Research","Chromosomal and Genetic Variations","MicroRNA in disease regulation"],"mesh_terms":["Gene Expression Regulation, Plant","RNA, Plant","Evolution, Molecular","RNA Stability","MicroRNAs"],"keywords":["Biology","Biogenesis","microRNA","Conserved sequence","Computational biology","Complementarity (molecular biology)","Gene","Genetics","RNA","Small RNA","Peptide sequence"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T02:30:06.834125Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}