{"doi":"10.1103/physrevlett.99.178104","title":"Importance of Metastable States in the Free Energy Landscapes of Polypeptide Chains","abstract":null,"journal":"Physical Review Letters","year":2007,"id":649589,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":68967,"name":"Mark A. 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The complexity of the landscape increases only moderately with the length of the chain. Analysis of the temperature dependence of these landscapes reveals that the stability of specific metastable states is maximal at a temperature close to the midpoint of folding. These mestastable states are therefore likely to be of particular significance in determining the generic tendency of proteins to aggregate into potentially pathogenic agents.","is_dataset_classified":null,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17995375","pmcid":null,"openalex_id":"https://openalex.org/W1978675310","authors":[],"funders":[{"funder_name":"Engineering and Physical Sciences Research Council","grant_id":"EP/D072751/1","title":null}],"total_grants":1,"fwci":1.51,"citation_percentile":0.80586927,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":4},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2019,"count":3},{"year":2023,"count":3}],"oa_status":"green","license":"http://link.aps.org/licenses/aps-default-license","oa_locations":[{"url":"https://arxiv.org/pdf/0710.3532","host_type":"repository"},{"url":"https://arxiv.org/pdf/0710.3532","host_type":"GREEN"},{"url":"https://arxiv.org/pdf/0710.3532","host_type":"repository"},{"url":"http://link.aps.org/article/10.1103/PhysRevLett.99.178104","host_type":"publisher"},{"url":"http://harvest.aps.org/v2/journals/articles/10.1103/PhysRevLett.99.178104/fulltext","host_type":"publisher"},{"url":"http://arxiv.org/abs/0710.3532","host_type":"repository"},{"url":"https://doi.org/10.1103/physrevlett.99.178104","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17995375","host_type":"repository"}],"fields_of_study":["Protein Structure and Dynamics","Enzyme Structure and Function","Advanced Proteomics Techniques and Applications","Physics","Medicine","Biology","Chemistry"],"mesh_terms":["Hydrogen Bonding","Models, Molecular","Peptide Fragments","Protein Conformation","Proteins","Thermodynamics","Protein Folding","Entropy","Hydrophobic and Hydrophilic Interactions"],"keywords":["Metastability","Energy landscape","Maxima and minima","Folding (DSP implementation)","Chemical physics","Chain (unit)","Protein folding","Aggregate (composite)","Hydrogen bond","Crystallography","Materials science","Chemistry","Thermodynamics","Physics","Molecule","Nanotechnology","Mathematics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T03:58:31.317863Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}