{"doi":"10.1103/physrevlett.78.1667","title":"Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)","abstract":"By exploiting the extremely large effective cross sections ( ${10}^{\\ensuremath{-}17}--{10}^{\\ensuremath{-}16}{\\mathrm{cm}}^{2}/\\mathrm{molecule}$) available from surface-enhanced Raman scattering (SERS), we achieved the first observation of single molecule Raman scattering. Measured spectra of a single crystal violet molecule in aqueous colloidal silver solution using one second collection time and about $2\\ifmmode\\times\\else\\texttimes\\fi{}{10}^{5}\\mathrm{W}/{\\mathrm{cm}}^{2}$ nonresonant near-infrared excitation show a clear ``fingerprint'' of its Raman features between 700 and $1700{\\mathrm{cm}}^{\\ensuremath{-}1}$. Spectra observed in a time sequence for an average of 0.6 dye molecule in the probed volume exhibited the expected Poisson distribution for actually measuring 0, 1, 2, or 3 molecules.","journal":"Physical Review Letters","year":1997,"id":11159,"datarank":23.357659777249342,"base_score":8.808518618782816,"endowment":8.808518618782816,"self_citation_contribution":1.3212777928174226,"citation_network_contribution":22.03638198443192,"self_endowment_contribution":1.3212777928174226,"citer_contribution":22.03638198443192,"corpus_percentile":95.1,"corpus_rank":1734,"citation_count":6690,"citer_count":193,"citers_with_citation_signal":193,"citers_with_endowment":193,"datacite_reuse_total":0,"is_dataset":false,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"1997-03-03","authors":[{"id":45531,"name":"Yang Wang","orcid":"0000-0001-9385-7393","position":1,"is_corresponding":false},{"id":90017,"name":"Harald Kneipp","orcid":null,"position":2,"is_corresponding":false},{"id":90018,"name":"Lev T. Perelman","orcid":"0000-0002-5617-8241","position":3,"is_corresponding":false},{"id":90019,"name":"Irving Itzkan","orcid":null,"position":4,"is_corresponding":false},{"id":90020,"name":"Ramachandra R. Dasari","orcid":null,"position":5,"is_corresponding":false},{"id":90021,"name":"Michael S. Feld","orcid":"0000-0001-6755-5287","position":6,"is_corresponding":false},{"id":90016,"name":"Katrin Kneipp","orcid":null,"position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}