{"doi":"10.1103/physreve.108.064407","title":"Physical limits to membrane curvature sensing by a single protein","abstract":null,"journal":"Physical Review E","year":2023,"id":621928,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":1,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":916389,"name":"Brian A. Camley","orcid":"0000-0002-0765-6956","position":1,"is_corresponding":false},{"id":1606263,"name":"Indrajit Badvaram","orcid":"0000-0002-1443-7065","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Physical limits to membrane curvature sensing by a single protein","abstract":"Membrane curvature sensing is essential for a diverse range of biological processes. Recent experiments have revealed that a single nanometer-sized septin protein has different binding rates to membrane-coated glass beads of 1-µm and 3-µm diameters, even though the septin is orders of magnitude smaller than the beads. This sensing ability is especially surprising since curvature-sensing proteins must deal with persistent thermal fluctuations of the membrane, leading to discrepancies between the bead's curvature and the local membrane curvature sensed instantaneously by a protein. Using continuum models of fluctuating membranes, we investigate whether it is feasible for a protein acting as a perfect observer of the membrane to sense micron-scale curvature either by measuring local membrane curvature or by using bilayer lipid densities as a proxy. To do this, we develop algorithms to simulate lipid density and membrane shape fluctuations. We derive physical limits to the sensing efficacy of a protein in terms of protein size, membrane thickness, membrane bending modulus, membrane-substrate adhesion strength, and bead size. To explain the experimental protein-bead association rates, we develop two classes of predictive models: (i) for proteins that maximally associate to a preferred curvature and (ii) for proteins with enhanced association rates above a threshold curvature. We find that the experimentally observed sensing efficacy is close to the theoretical sensing limits imposed on a septin-sized protein. Protein-membrane association rates may depend on the curvature of the bead, but the strength of this dependence is limited by the fluctuations in membrane height and density.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":1,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38243534","pmcid":null,"openalex_id":"https://openalex.org/W4389555711","authors":[],"funders":[{"funder_name":"National Science Foundation","grant_id":"DMR 1945141","title":null},{"funder_name":"National Science Foundation","grant_id":"OAC1920103","title":null},{"funder_name":"National Science Foundation","grant_id":"1945141","title":"CAREER: Theory of Membrane Shape Sensing at the Micron Scale"}],"total_grants":3,"fwci":0.9274,"citation_percentile":0.72902226,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"closed","license":"APS Licenses for Journal Article Re-use","oa_locations":[{"url":"https://arxiv.org/pdf/2210.12204","host_type":"GREEN"},{"url":"https://link.aps.org/article/10.1103/PhysRevE.108.064407","host_type":"publisher"},{"url":"http://harvest.aps.org/v2/journals/articles/10.1103/PhysRevE.108.064407/fulltext","host_type":"publisher"},{"url":"https://doi.org/10.1103/physreve.108.064407","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38243534","host_type":"repository"},{"url":"https://dx.doi.org/10.48550/arxiv.2210.12204","host_type":""},{"url":"http://arxiv.org/abs/2210.12204","host_type":""}],"fields_of_study":["Lipid Membrane Structure and Behavior","Force Microscopy Techniques and Applications","Mechanical and Optical Resonators","Physics","Biology","Medicine","0301 basic medicine","0303 health sciences","03 medical and health sciences","Cell Membrane","Lipid Bilayers","Septins","Proteins"],"mesh_terms":["Cell Membrane","Lipid Bilayers","Proteins","Septins"],"keywords":["Curvature","Membrane curvature","Membrane","Lipid bilayer","Elasticity of cell membranes","Thermal fluctuations","Biophysics","Membrane protein","Materials science","Physics","Chemistry","Integral membrane protein","Biology","Geometry","Thermodynamics","Biochemistry","Mathematics","Quantitative Biology - Subcellular Processes","Cell Membrane","Lipid Bilayers","Proteins","FOS: Physical sciences","Condensed Matter - Soft Condensed Matter","Biological Physics (physics.bio-ph)","FOS: Biological sciences","Soft Condensed Matter (cond-mat.soft)","Physics - Biological Physics","Subcellular Processes (q-bio.SC)","Septins"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.48550/arxiv.2210.12204","title":"Physical limits to membrane curvature sensing by a single protein","publisher":"arXiv","resource_type":"Text"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T16:54:45.118143Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}