{"doi":"10.1103/physreve.102.022406","title":"Processivity of molecular motors under vectorial loads","abstract":null,"journal":"Physical Review E","year":2020,"id":608568,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":814054,"name":"Mohammed Mahamdeh","orcid":"0000-0003-3985-6992","position":1,"is_corresponding":false},{"id":532203,"name":"Zoltán Neufeld","orcid":"0000-0003-3236-9278","position":2,"is_corresponding":false},{"id":792382,"name":"Hamid Khataee","orcid":"0000-0002-9122-3220","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Processivity of molecular motors under vectorial loads","abstract":"Molecular motors are cellular machines that drive the spatial organization of the cells by transporting cargos along intracellular filaments. Although the mechanical properties of single molecular motors are relatively well characterized, it remains elusive how the geometry of a load imposed on a motor affects its processivity, i.e., the average distance that a motor moves per interaction with a filament. Here, we theoretically explore this question for a single-kinesin molecular motor by analyzing the load dependence of the stepping and detachment processes. We find that the processivity of the kinesin increases with lowering the load angle between the kinesin and the microtubule filament, due to the deceleration of the detachment rate. When the load angle is large, the processivity is predicted to enhance with accelerating the stepping rate through an optimal distribution of the load over the kinetic transition rates underlying a mechanical step of the motor. These results provide new insights into understanding of the design of potential synthetic biomolecular machines that can travel long distances with high velocities.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32942474","pmcid":null,"openalex_id":"https://openalex.org/W3053499459","authors":[],"funders":[],"total_grants":0,"fwci":0.1095,"citation_percentile":0.42891206,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2024,"count":2}],"oa_status":"closed","license":"https://link.aps.org/licenses/aps-default-license","oa_locations":[{"url":"https://link.aps.org/article/10.1103/PhysRevE.102.022406","host_type":"publisher"},{"url":"http://harvest.aps.org/v2/journals/articles/10.1103/PhysRevE.102.022406/fulltext","host_type":"publisher"},{"url":"https://doi.org/10.1103/physreve.102.022406","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32942474","host_type":"repository"}],"fields_of_study":["Microtubule and mitosis dynamics","Micro and Nano Robotics","Protein Structure and Dynamics"],"mesh_terms":["Biomechanical Phenomena","Models, Biological","Kinesins"],"keywords":["Processivity","Molecular motor","Kinesin","Protein filament","Microtubule","Physics","Mechanics","Nanotechnology","Materials science","Biology","Nuclear magnetic resonance"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T18:41:06.626811Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}