{"doi":"10.1103/physreve.100.022408","title":"Limited processivity of single motors improves overall transport flux of self-assembled motor-cargo complexes","abstract":null,"journal":"Physical Review E","year":2019,"id":630925,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1634781,"name":"Shengtan Mao","orcid":null,"position":1,"is_corresponding":false},{"id":370980,"name":"M. Gregory Forest","orcid":"0000-0002-7718-4456","position":2,"is_corresponding":false},{"id":285635,"name":"Samuel K. Lai","orcid":"0000-0003-4721-528X","position":3,"is_corresponding":false},{"id":490637,"name":"Jay Newby","orcid":"0000-0001-9988-2020","position":4,"is_corresponding":false},{"id":1412556,"name":"Keshav B. Patel","orcid":"0009-0001-8125-8366","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Limited processivity of single motors improves overall transport flux of self-assembled motor-cargo complexes","abstract":"Single kinesin molecular motors can processively move along a microtubule (MT) a few micrometers on average before dissociating. However, cellular length scales over which transport occurs are several hundred microns and more. Why seemingly unreliable motors are used to transport cellular cargo remains poorly understood. We propose a theory for how low processivity, the average length of a single bout of directed motion, can enhance cellular transport when motors and cargos must first diffusively self-assemble into complexes. We employ stochastic modeling to determine the effect of processivity on overall cargo transport flux. We show that, under a wide range of physiologically relevant conditions, possessing \"infinite\" processivity does not maximize flux along MTs. Rather, we find that lowering processivity, i.e., weaker binding of motors to MTs, can improve transport flux. These results shed light on the relationship between processivity and transport efficiency and offer a theory for the physiological benefits of low motor processivity.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31574716","pmcid":null,"openalex_id":"https://openalex.org/W2915596969","authors":[],"funders":[{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"RGPIN-2019-06435","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"RGPAS-2019-00014","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"DGECR-2019-00321","title":null},{"funder_name":"David and Lucile Packard Foundation","grant_id":"2013-39274","title":null},{"funder_name":"National Science Foundation","grant_id":"DMR-1810168","title":null},{"funder_name":"National Science Foundation","grant_id":"DMS-1462992","title":null},{"funder_name":"National Science Foundation","grant_id":"DMS-1664645","title":null},{"funder_name":"National Science Foundation","grant_id":"DMS-1517274","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R01HL141934","title":null},{"funder_name":"University of Alberta","grant_id":"","title":null}],"total_grants":10,"fwci":0.1016,"citation_percentile":0.38447112,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2023,"count":1}],"oa_status":"green","license":"https://link.aps.org/licenses/aps-default-accepted-manuscript-license","oa_locations":[{"url":"https://arxiv.org/pdf/1902.09672","host_type":"repository"},{"url":"https://arxiv.org/pdf/1902.09672","host_type":"repository"},{"url":"https://link.aps.org/accepted/10.1103/PhysRevE.100.022408","host_type":"publisher"},{"url":"https://link.aps.org/article/10.1103/PhysRevE.100.022408","host_type":"publisher"},{"url":"http://harvest.aps.org/v2/journals/articles/10.1103/PhysRevE.100.022408/fulltext","host_type":"publisher"},{"url":"http://arxiv.org/abs/1902.09672","host_type":"repository"},{"url":"https://doi.org/10.1103/physreve.100.022408","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31574716","host_type":"repository"}],"fields_of_study":["Microtubule and mitosis dynamics","Stochastic processes and statistical mechanics","Micro and Nano Robotics"],"mesh_terms":["Biological Transport","Kinetics","Models, Biological","Monte Carlo Method","Protein Binding","Molecular Motor Proteins"],"keywords":["Processivity","Molecular motor","Kinesin","Microtubule","Flux (metallurgy)","Physics","Biophysics","Chemistry","Biology","Cell biology","Nuclear magnetic resonance"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T22:26:35.073975Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}