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Induction of the enhancer may have a role in the increase in globin gene transcription that characterizes erythroid maturation. Enhancer activity appears to be mediated by the binding of a complex of proteins from the jun and fos families to tandem AP-1 consensus sequences.</jats:p>","journal":"Genes &amp; Development","year":1990,"id":16007,"datarank":15.40153745051702,"base_score":5.703782474656201,"endowment":5.703782474656201,"self_citation_contribution":0.8555673711984303,"citation_network_contribution":14.54597007931859,"self_endowment_contribution":0.8555673711984303,"citer_contribution":14.54597007931859,"corpus_percentile":null,"corpus_rank":null,"citation_count":299,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":119806,"name":"B P Sorrentino","orcid":null,"position":1,"is_corresponding":false},{"id":119807,"name":"K T McDonagh","orcid":null,"position":2,"is_corresponding":false},{"id":119808,"name":"A W Nienhuis","orcid":null,"position":3,"is_corresponding":false},{"id":119805,"name":"P A Ney","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.703782474656201,"endowment":5.703782474656201,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"2116990","pmcid":null,"openalex_id":"https://openalex.org/W2087652779","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":3,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":3},{"year":2014,"count":3},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"gold","license":null,"oa_locations":[{"url":"http://genesdev.cshlp.org/content/4/6/993.full.pdf","host_type":"journal"},{"url":"http://genesdev.cshlp.org/content/4/6/993.full.pdf","host_type":"GOLD"},{"url":"http://genesdev.cshlp.org/content/4/6/993.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1101/gad.4.6.993","host_type":"publisher"},{"url":"https://doi.org/10.1101/gad.4.6.993","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/2116990","host_type":"repository"}],"fields_of_study":["RNA and protein synthesis mechanisms","CRISPR and Genetic Engineering","DNA and Nucleic Acid Chemistry","Biology","Medicine","Base Sequence","Binding Sites","DNA","DNA-Binding Proteins","Enhancer Elements, Genetic","Erythrocytes","Gene Expression Regulation","Globins","HeLa Cells","Humans","Leukemia, Erythroblastic, Acute","Molecular Sequence Data","Proto-Oncogene Proteins c-jun","Restriction Mapping","Transcription Factors","Tumor Cells, Cultured"],"mesh_terms":["Base Sequence","Binding Sites","DNA","DNA-Binding Proteins","Enhancer Elements, Genetic","Erythrocytes","Leukemia, Erythroblastic, Acute","Gene Expression Regulation","Globins","HeLa Cells","Humans","Molecular Sequence Data","Transcription Factors","Tumor Cells, Cultured","Restriction Mapping","Proto-Oncogene Proteins c-jun","Hela Cells"],"keywords":["Enhancer","Biology","Locus control region","Enhancer RNAs","Molecular biology","Globin","Transcription (linguistics)","Enhancer trap","Transcription factor","Gene","Regulation of gene expression","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T19:54:06.087363Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}