{"doi":"10.1101/gad.353241.125","title":"End of the line: a kinetic ruler model for poly(A) tail termination","abstract":"Polyadenylation of mRNA is a key step in post-transcriptional regulation. In this issue of Genes & Development , Gabs and colleagues (doi:10.1101/gad.352912.125) provide evidence for a novel, kinetically driven mechanism that dictates the length of poly(A) tails added to mRNAs in budding yeast. The investigators introduce the concept of Nab2, a zinc finger poly(A) RNA binding protein, as a “kinetic ruler,” which functions through dynamic competition with the cleavage and polyadenylation complex (CPAC) to define the length of poly(A) tails.","journal":"Genes & Development","year":2025,"id":573351,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9433,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":430731,"name":"Anita H. Corbett","orcid":"0000-0002-0461-6895","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:57:32.445190Z","pmid":"40858502","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}