{"doi":"10.1101/gad.353189.125","title":"A new link in the leukemia genetic puzzle","abstract":"Growing disparities in treatment outcomes for acute myeloid leukemia (AML) call for particular attention to features of the disease that vary among populations. In this issue of Genes & Development , Pawar and colleagues (doi:10.1101/gad.352602.125) now reveal that mutations in PHIP , more prevalent among Black patients with AML, disrupt the function of the chromatin regulator PHF6. They corroborate that the latter protein represses gene transcription upon binding open and active regions of chromatin and show that PHF6 missense mutations observed in AML result in loss of function. These insights advance our understanding of disease pathogenesis and may inform efforts to address racial disparities in treatment.","journal":"Genes & Development","year":2025,"id":558736,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9452,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":35287,"name":"Ross L. Levine","orcid":"0000-0002-7884-1905","position":1,"is_corresponding":false},{"id":564363,"name":"Xiaodi Wu","orcid":"0000-0003-0886-8640","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:55:30.312295Z","pmid":"40796297","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}