{"doi":"10.1101/gad.352632.125","title":"TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions","abstract":"The TEAD family of transcription factors is best known as the DNA-binding factor in the Hippo pathway, where these factors act by interacting with transcriptional coactivators YAP and TAZ (YAP/TAZ). Despite the importance of the Hippo pathway, the in vivo functions of TEAD in mammals have not been well established. By comparing mouse mutants lacking TEAD1 and TEAD2 (TEAD1/2) with those lacking YAP/TAZ, we found that TEAD1/2 have both YAP/TAZ-dependent and YAP/TAZ-independent functions during ventral telencephalon development. TEAD1/2 loss and YAP/TAZ loss similarly disrupt neuroepithelial apical junctions. However, the impacts of their losses on progenitor lineage progression are essentially opposite: YAP/TAZ loss depletes early progenitors and increases later progenitors, consistent with their established function in promoting progenitor self-renewal and proliferation, whereas TEAD1/2 loss expands early progenitors and reduces late progenitors, indicating that TEAD1/2 promote lineage progression. We further show that TEAD1/2 promote neural progenitor lineage progression by at least in part inhibiting Notch signaling and by cooperating with insulinoma-associated 1 (INSM1). Orthologs of TEAD and INSM1 have been shown to cooperatively regulate neuronal cell fate decisions in worms and flies. Our study reveals a remarkable evolutionary conservation of the function of this transcription factor complex during metazoan neural development.","journal":"Genes & Development","year":2025,"id":556332,"datarank":0.17788462337745986,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.013092780077243411,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.013092780077243411,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE285025"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":674522,"name":"Alfonso Lavado","orcid":null,"position":1,"is_corresponding":false},{"id":765419,"name":"Venkata Thulabandu","orcid":"0000-0003-3184-5121","position":2,"is_corresponding":false},{"id":577340,"name":"Cody A. Ramirez","orcid":"0000-0001-5598-0876","position":3,"is_corresponding":false},{"id":674523,"name":"Joshua Paré","orcid":null,"position":4,"is_corresponding":false},{"id":679293,"name":"Rajiv Dixit","orcid":null,"position":5,"is_corresponding":false},{"id":890375,"name":"Akhilesh Mishra","orcid":"0000-0002-0990-2540","position":6,"is_corresponding":false},{"id":1368425,"name":"Jiyuan Yang","orcid":"0000-0003-0185-1133","position":7,"is_corresponding":false},{"id":55257,"name":"Jiyang Yu","orcid":"0000-0003-1244-4429","position":8,"is_corresponding":false},{"id":673631,"name":"Xinwei Cao","orcid":"0000-0003-0651-5243","position":9,"is_corresponding":false},{"id":518851,"name":"Charles H. Perry","orcid":"0000-0001-9338-4426","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T02:55:08.896385Z","pmid":"40389325","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}