{"doi":"10.1101/gad.349150.121","title":"NDF is a transcription factor that stimulates elongation by RNA polymerase II","abstract":"RNA polymerase II (Pol II) elongation is a critical step in gene expression. Here we found that NDF, which was identified as a bilaterian nucleosome-destabilizing factor, is also a Pol II transcription factor that stimulates elongation with plain DNA templates in the absence of nucleosomes. NDF binds directly to Pol II and enhances elongation by a different mechanism than that used by transcription factor TFIIS. Moreover, yeast Pdp3, which is related to NDF, binds to Pol II and stimulates elongation. Thus, NDF is a Pol II binding transcription elongation factor that is localized over gene bodies and is conserved from yeast to humans.","journal":"Genes & Development","year":2022,"id":299105,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":498748,"name":"Jun Xu","orcid":"0009-0001-1360-2778","position":1,"is_corresponding":false},{"id":335173,"name":"Ziwei Li","orcid":"0000-0003-4893-0971","position":2,"is_corresponding":false},{"id":988560,"name":"Kevin Xu","orcid":"0000-0003-0233-2669","position":3,"is_corresponding":false},{"id":498750,"name":"Dong Wang","orcid":"0000-0002-2829-1546","position":4,"is_corresponding":false},{"id":988561,"name":"George A. Kassavetis","orcid":"0000-0001-6857-5271","position":5,"is_corresponding":false},{"id":80489,"name":"James T. Kadonaga","orcid":"0000-0002-2075-9458","position":6,"is_corresponding":false},{"id":988559,"name":"Jia Fei","orcid":"0000-0003-0612-6176","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T00:31:40.528568Z","pmid":"35273076","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}