{"doi":"10.1101/gad.330464.119","title":"A single-cell atlas of the developing <i>Drosophila</i> ovary identifies follicle stem cell progenitors","abstract":"Addressing the complexity of organogenesis at a system-wide level requires a complete understanding of adult cell types, their origin, and precursor relationships. The Drosophila ovary has been a model to study how coordinated stem cell units, germline, and somatic follicle stem cells maintain and renew an organ. However, lack of cell type-specific tools have limited our ability to study the origin of individual cell types and stem cell units. Here, we used a single-cell RNA sequencing approach to uncover all known cell types of the developing ovary, reveal transcriptional signatures, and identify cell type-specific markers for lineage tracing. Our study identifies a novel cell type corresponding to the elusive follicle stem cell precursors and predicts subtypes of known cell types. Altogether, we reveal a previously unanticipated complexity of the developing ovary and provide a comprehensive resource for the systematic analysis of ovary morphogenesis.","journal":"Genes & Development","year":2020,"id":118378,"datarank":2.3446448504930095,"base_score":4.574710978503383,"endowment":4.574710978503383,"self_citation_contribution":0.6862066467755076,"citation_network_contribution":1.658438203717502,"self_endowment_contribution":0.6862066467755076,"citer_contribution":1.658438203717502,"corpus_percentile":null,"corpus_rank":null,"citation_count":96,"citer_count":86,"citers_with_citation_signal":63,"citers_with_endowment":63,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9211,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":550465,"name":"Torsten U. Banisch","orcid":"0000-0002-9995-1580","position":1,"is_corresponding":false},{"id":551318,"name":"Selena Gupta","orcid":null,"position":2,"is_corresponding":false},{"id":63535,"name":"Ruth Lehmann","orcid":"0000-0002-8454-5651","position":3,"is_corresponding":false},{"id":550464,"name":"Maija Slaidina","orcid":"0000-0002-2235-9511","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:13:58.531532Z","pmid":"31919193","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}