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We propose a new model in which TAFs function as reinitiation factors, accounting for the differential responses of promoters to various transcription factor mutations.</jats:p>","journal":"Genes &amp; Development","year":2017,"id":588493,"datarank":2.1391893517636893,"base_score":4.276666119016055,"endowment":4.276666119016055,"self_citation_contribution":0.6414999178524083,"citation_network_contribution":1.4976894339112807,"self_endowment_contribution":0.6414999178524083,"citer_contribution":1.4976894339112807,"corpus_percentile":null,"corpus_rank":null,"citation_count":71,"citer_count":55,"citers_with_citation_signal":50,"citers_with_endowment":50,"datacite_reuse_total":16,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":227599,"name":"Scott B. 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Although the TATA-binding protein (TBP) subunit of TFIID is necessary and sufficient for in vitro transcription, the TBP-associated factor (TAF) subunits recognize downstream promoter elements, act as coactivators, and interact with nucleosomes. In yeast nuclear extracts, transcription induces stable TAF binding to downstream promoter DNA, promoting subsequent activator-independent transcription reinitiation. In vivo, promoter responses to TAF mutations correlate with the level of downstream, rather than overall, Taf1 cross-linking. We propose a new model in which TAFs function as reinitiation factors, accounting for the differential responses of promoters to various transcription factor mutations.</jats:p>","is_dataset_classified":null,"base_score":4.276666119016055,"endowment":4.276666119016055,"datacite_reuse_total":16,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29203645","pmcid":"PMC5749164","openalex_id":"https://openalex.org/W2950346133","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"GM46498","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM046498","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01GM046498-20","title":"The RNA polymerase II transcription complex"},{"funder_name":"Blais Proteomics Center","grant_id":"","title":null},{"funder_name":"Dana-Farber Cancer 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