{"doi":"10.1101/gad.189514.112","title":"PRORP proteins support RNase P activity in both organelles and the nucleus in <i>Arabidopsis</i>","abstract":"<jats:p>RNase P is an essential enzyme that cleaves the 5′ leader sequence of tRNA precursors. RNase Ps were believed until now to occur universally as ribonucleoproteins in organisms performing RNase P activity. Here we find that protein-only RNase P enzymes called PRORP (for proteinaceous RNase P) support RNase P activity in vivo in both organelles and the nucleus in <jats:italic>Arabidopsis</jats:italic>. Beyond tRNA, PRORP proteins are involved in the maturation of small nucleolar RNA (snoRNA) and mRNA. Finally, ribonucleoprotein RNase MRP is not involved in tRNA maturation in plants. Altogether, our results indicate that ribonucleoprotein enzymes have been entirely replaced by proteins for RNase P activity in plants.</jats:p>","journal":"Genes &amp; Development","year":2012,"id":594717,"datarank":0.7266280629687888,"base_score":4.844187086458591,"endowment":4.844187086458591,"self_citation_contribution":0.7266280629687888,"citation_network_contribution":0.0,"self_endowment_contribution":0.7266280629687888,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":126,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1522564,"name":"Anthony Gobert","orcid":null,"position":1,"is_corresponding":false},{"id":536407,"name":"Philippe Giegé","orcid":"0000-0003-2285-8190","position":2,"is_corresponding":false},{"id":1522563,"name":"Bernard Gutmann","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"PRORP proteins support RNase P activity in both organelles and the nucleus in <i>Arabidopsis</i>","abstract":"<jats:p>RNase P is an essential enzyme that cleaves the 5′ leader sequence of tRNA precursors. RNase Ps were believed until now to occur universally as ribonucleoproteins in organisms performing RNase P activity. Here we find that protein-only RNase P enzymes called PRORP (for proteinaceous RNase P) support RNase P activity in vivo in both organelles and the nucleus in <jats:italic>Arabidopsis</jats:italic>. Beyond tRNA, PRORP proteins are involved in the maturation of small nucleolar RNA (snoRNA) and mRNA. Finally, ribonucleoprotein RNase MRP is not involved in tRNA maturation in plants. Altogether, our results indicate that ribonucleoprotein enzymes have been entirely replaced by proteins for RNase P activity in plants.</jats:p>","is_dataset_classified":null,"base_score":4.844187086458591,"endowment":4.844187086458591,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22549728","pmcid":"PMC3360558","openalex_id":"https://openalex.org/W1995829416","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":16},{"year":2014,"count":12},{"year":2015,"count":13},{"year":2016,"count":15},{"year":2017,"count":12},{"year":2018,"count":7},{"year":2019,"count":7},{"year":2020,"count":5},{"year":2021,"count":8},{"year":2022,"count":7},{"year":2023,"count":9},{"year":2024,"count":4},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"gold","license":null,"oa_locations":[{"url":"http://genesdev.cshlp.org/content/26/10/1022.full.pdf","host_type":"journal"},{"url":"http://genesdev.cshlp.org/content/26/10/1022.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1101/gad.189514.112","host_type":"publisher"},{"url":"https://doi.org/10.1101/gad.189514.112","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22549728","host_type":"repository"},{"url":"https://research-repository.uwa.edu.au/en/publications/cb59fbef-7e5a-4891-bfb3-3f90d6bae190","host_type":"repository"},{"url":"https://hal.archives-ouvertes.fr/hal-00701324","host_type":"repository"},{"url":"https://hal.science/hal-03261665","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3360558","host_type":"repository"}],"fields_of_study":["RNA Research and Splicing","RNA modifications and cancer","RNA and protein synthesis mechanisms","Arabidopsis","Arabidopsis Proteins","Cell Nucleus","Mitochondria","RNA Processing, Post-Transcriptional","RNA, Messenger","RNA, Small Nucleolar","RNA, Transfer","Ribonuclease P","Ribonucleoproteins"],"mesh_terms":["Cell Nucleus","Mitochondria","Ribonucleoproteins","RNA Processing, Post-Transcriptional","RNA, Messenger","RNA, Transfer","Arabidopsis","RNA, Small Nucleolar","Arabidopsis Proteins","Ribonuclease P"],"keywords":["RNase P","RNase MRP","Ribonucleoprotein","RNase PH","Biology","Transfer RNA","Arabidopsis","RNA","Exosome complex","Ribonuclease","Biochemistry","Cell biology","Organelle","Molecular biology","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T15:21:43.981044Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}