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The results support a new, multifactorial model that describes how genotoxic stress enables BRCA1 to execute a diverse set of DNA damage-response functions.</jats:p>","journal":"Genes &amp; Development","year":2006,"id":593546,"datarank":0.8595149674460364,"base_score":5.730099782973575,"endowment":5.730099782973575,"self_citation_contribution":0.8595149674460364,"citation_network_contribution":0.0,"self_endowment_contribution":0.8595149674460364,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":307,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1519121,"name":"Bijan Sobhian","orcid":null,"position":1,"is_corresponding":false},{"id":29959,"name":"Shailja Pathania","orcid":"0000-0001-8974-6420","position":2,"is_corresponding":false},{"id":246228,"name":"Sharon B. 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Two distinct DNA damage-dependent super complexes emerged; their activation was dependent, in part, on the actions of specific checkpoint kinases, and each super complex contributed to a distinctive aspect of the DNA damage response. The results support a new, multifactorial model that describes how genotoxic stress enables BRCA1 to execute a diverse set of DNA damage-response functions.</jats:p>","is_dataset_classified":null,"base_score":5.730099782973575,"endowment":5.730099782973575,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16391231","pmcid":"PMC1356099","openalex_id":"https://openalex.org/W2164458581","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2012,"count":23},{"year":2013,"count":19},{"year":2014,"count":21},{"year":2015,"count":19},{"year":2016,"count":10},{"year":2017,"count":10},{"year":2018,"count":12},{"year":2019,"count":4},{"year":2020,"count":14},{"year":2021,"count":17},{"year":2022,"count":13},{"year":2023,"count":11},{"year":2024,"count":4},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"gold","license":null,"oa_locations":[{"url":"http://genesdev.cshlp.org/content/20/1/34.full.pdf","host_type":"journal"},{"url":"http://genesdev.cshlp.org/content/20/1/34.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1101/gad.1381306","host_type":"publisher"},{"url":"https://doi.org/10.1101/gad.1381306","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16391231","host_type":"repository"},{"url":"https://escholarship.umassmed.edu/cancerbiology_pp/4","host_type":""},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1356099","host_type":"repository"}],"fields_of_study":["DNA Repair Mechanisms","Carcinogens and Genotoxicity Assessment","CRISPR and Genetic Engineering"],"mesh_terms":["MRE11 Homologue Protein","Carrier Proteins","Cell Cycle","DNA Damage","DNA Repair","DNA-Binding Proteins","Humans","Nuclear Proteins","Protein Binding","Acid Anhydride Hydrolases","Cell Cycle Proteins","BRCA1 Protein","Tumor Suppressor Proteins","Ubiquitin-Protein Ligases","DNA Repair Enzymes","Cell Line, Tumor"],"keywords":["DNA damage","Biology","DNA repair","G2-M DNA damage checkpoint","DNA","Rad50","Cell biology","CHEK1","Genetics","Gene","DNA-binding protein","Cell cycle checkpoint","Transcription factor","Cell cycle"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T11:24:56.555948Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}